Center for Human and Natural Sciences, Federal University of ABC, Santo André SP, Brazil Department of Materials Engineering, Faculty of Mechanical Engineering, State University of Campinas, Campinas SP, Brazil Biomaterials Laboratory, Center for Medical and Biological Sciences, Catholic University of São Paulo, Sorocaba SP, Brazil Department of Cell Biology, Institute of Biology, State Univers...

attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (plga) and doxorubicin. biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. plga nanoparticles were formulated by sonication method. lactide/glycolide ratio a...

Polymers of lactic and glycolic acid are attractive candidates to fabricate devides to transplant cells and engineer new tissues. These polymers are biocompatible, and exhibit a wide range of erosion times and mechanical properties. This manuscript describes the fabrication and characterization, in vitro and in vivo, of hollow, tubular devices from porous films of various polymers of this famil...

A novel bone regeneration technology is expected to be developed using scaffolds and activities of osteoblasts, instead of the traditional bone filling surgery. Here, the cellular bone formation activities are accelerated by the transplantation of porous scaffold materials as bone filling substitutes, resulting the complete bone regeneration by hydrolytic resorption of scaffold materials and re...

Purpose: The purpose of this study is to compare the time-course changes in condylar long axis and skeletal stability after sagittal split ramus osteotomy (SSRO) with unsintered hydroxyapatite (u-HA) / poly-L-lactic acid (PLLA) plate, PLLA plate versus titanium plate. Patients and Methods: Of 60 Japanese patients diagnosed of mandibular prognathism, 20 underwent SSRO with u-HA/PLLA plate system...

The ability of some microorganisms to use lactic acid stereocopolymers and copolymers with glycolic acid as sole carbon and energy sources was studied under controlled or natural conditions. First, 14 filamentous fungal strains were tested in liquid cultures, adopting total lactic acid consumption, nitrogen source exhaustion, and maximal biomass production as selection criteria. Two strains of ...