BACKGROUND Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate) (PAA-MMA) incorporating cisplatin and their antitumor activity in vitro and in vivo. METHODS Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acr...

We developed novel acrylic-based polymers that can be used as mucoadhesive delivery systems. Poly(acrylic acid) hydrogels were modified by grafting adhesion promoter chains such as poly(ethylene glycol) (PEG) onto their back-bone chains, thus promoting the adhesive process by interpenetration. The copolymers synthesized were designated as P(AA-g-EG). Hydrogels were synthesized using PEG of two ...

Abstract: Introduction: The controlled release of medicaments in the management diabetes is desirable to have a better therapeutic activity drug. Objectives: In present study hydrogels were prepared as drug delivery system taking Rosiglitazone model Materials and Methods: Hydrogels created using Free Radical Polymerization approach, with crosslinker N, N′-Methylene bisacrylamide serving binding...

A micropatterned multilayer film, which was fabricated from layer-by-layer electrostatic self-assembly of nitrodiazoresin (NDR)/poly(acrylic acid) (PAA) followed by photolithography, was utilized as a structured template for the biomimetic mineralization of calcium carbonate. Micropatterned CaCO3 films consisting of regularly aligned calcite crystals oriented in the <104> direction were selecti...

A novel, fast and simple method was developed to fabricate poly(acrylic acid sodium salt) microspheres (PAAS MSs). The resulting PAAS MSs were utilized as active templates to universally synthesize the mesoporous lanthanide-doped gadolinium oxide hollow nanospheres with multicolored upconversion emissions under mild conditions.

50 nm Magnetic nanocluster (MNC) was deliberately selected as an efficient probe for the magnetic relaxation switching (MRSw) assay. After surface modification of MNCs with poly(acrylic acid) to give PAA-MNCs, and employing streptavidin-biotin interactions for the MRSw assay model, a few tenths pM concentration of strepavidin could be determined.

Static and quasielastic light scattenng expenments have been performed on the reaction bath of partially neutralized poly(acrylic acid) solutions and gels. The intensity scattered from gels is independent on the scattenng wavevector, giving thus evidence that the gels are homogeneous at the scale of the wavelength of the light, contrary to what is generally observed in

The Brillouin shift and width for poly(acrylic acid) hydrogels have been obtained as a function of gel network volume fraction using a five-pass Fabry-Pdrot interferometer. A conspicuous peak has been observed in the Brillouin shift at high volume fraction. The results are discussed in the light of a theory for the Brillouin light-scattering from gels proposed by Marqusee and Deutch-

Crosslinked poly(acrylic acid)-b-polystyrene polymersomes were successfully employed to form a water-in-oil Pickering emulsion and enabled an easy and reversible disassembly due to the pH sensitivity. The side of the polymersomes exposed to the water phase was selectively modified with metal nanoparticles, allowing facile formation of anisotropically modified Janus polymersomes.