Extracts of Klebsiella pneumoniae oxidatively convert 1-phospho-5-S-methylthioribose (1-PMTR) to alpha-keto-gamma-methylthiobutyrate, a precursor of methionine, and to S-methylthiopropionate and formate. One equivalent of formate is produced per equivalent of alpha-keto-gamma-methylthiobutyrate and two equivalents of formate per equivalent of methylthiopropionate. Two compounds were identified ...

Specialized soft x-ray and vacuum ultraviolet ~VUV! diagnostics used to monitor impurity emissions from fusion plasmas are often placed in a very challenging experimental environment. Detectors in these diagnostics must be simple; mechanically robust; immune to electromagnetic interference, energetic particles, and magnetic fields up to several tesla; ultra-high-vacuum compatible; and able to w...

BACKGROUND Late Onset Tay- Sachs disease (LOTS) is a rare neurodegenerative lysosomal storage disease which results from mutations in the gene encoding the α subunit (HEXA) of β-hexosaminidase enzyme (HexA). At the present time, no effective treatment exists for LOTS and other neurodegenerative diseases involving the central nerve system (CNS). Pyrimethamine (PMT) was previously shown to act as...

Family systems theory posits that the relative effectiveness of early interventions will vary depending on various aspects of the family. This study tested whether maternal responsivity would predict the extent to which Prelinguistic Milieu Teaching (PMT) facilitated generalized intentional communication better than a contrast treatment that was conducted in a small group by a responsive adult ...

The cell walls of grasses such as wheat, maize, rice, and sugar cane, contain large amounts of ferulate that is ester-linked to the cell wall polysaccharide glucuronoarabinoxylan (GAX). This ferulate is considered to limit the digestibility of polysaccharide in grass biomass as it forms covalent linkages between polysaccharide and lignin components. Candidate genes within a grass-specific clade...

In this world of digital displays, almost all transducers generate analog signals. Whatever the device, whether it is making electrical, magnetic, mechanical, or optical measurements, i-ts output signal is likely to be analog rather than digital. One of the few exceptions is the photomultiplier tube (PMT). Its digital nature stems from the 1905 discovery by Einstein that the ejection of electro...

In this paper, we show that our proposed hybrid optoelectronic correlator (HOC), which correlates images using spatial light modulators (SLMs), detectors, and field-programmable gate arrays (FPGAs), is capable of detecting objects in a scale and rotation invariant manner, along with the shift invariance feature, by incorporating polar Mellin transform (PMT). For realistic images, we cut out a s...

We introduce an application of thermionic emission in a PMT photocathode. Because of the nonlinear dependence of thermionic emission on absorbed laser power, a conventional PMT is found to produce a virtual pinhole effect that rejects unfocused light at least as strongly as a physical pinhole. This virtual pinhole effect is exploited in a scanning transmission confocal microscope equipped with ...

BACKGROUND Paratonia, a form of hypertonia, is associated with loss of mobility and with the development of contractures especially in the late stages of the dementia. Passive movement therapy (PMT) currently is the main physiotherapeutic intervention. General doubt about the beneficial effects of this widely used therapy necessitates a randomised clinical trial (RCT) to study the efficacy of P...

Protein O-mannosyltransferases (PMTs) catalyze the initial reaction of protein O-mannosylation by transferring the first mannose unit onto serine and threonine residues of a nascent polypeptide being synthesized in the endoplasmic reticulum (ER). The PMTs are well conserved in eukaryotic organisms, and in vivo defects of these enzymes result in cell death in yeast and congenital diseases in hum...