نتایج جستجو برای: pluripotent stem cells

تعداد نتایج: 1506620  

2016
Vytautas Galvanauskas Vykantas Grincas Rimvydas Simutis

This paper investigates a possible practical solution for reasonable oxygen supply during the pluripotent stem cells expansion processes, where the stem cells propagate as aggregates in stirred-suspension bioreactors. Low glucose and low oxygen concentrations are preferred for efficient proliferation of pluripotent stem cells. However, strong oxygen limitation, especially inside of cell aggrega...

Journal: :Neuron 2013
Yanling Wang Ricardo Dolmetsch

Whether neurons generated in vitro from human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) have in vivo-like properties is unknown. In this issue of Neuron, Espuny-Camacho et al. (2013) show that ESC-/iPSC-derived cortical neurons make specific projections and functional synapses when transplanted into a neonatal mouse brain.

Journal: :American journal of physiology. Heart and circulatory physiology 2016
Luqia Hou Joseph J Kim Y Joseph Woo Ngan F Huang

Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. Notably, adult stem and progenitor cells including mononuclear cells, e...

Journal: :Stem cells and development 2011
Anyou Wang Kevin Huang Yin Shen Zhigang Xue Chaochao Cai Steve Horvath Guoping Fan

It has been debated whether human induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) express distinctive transcriptomes. By using the method of weighted gene co-expression network analysis, we showed here that iPSCs exhibit altered functional modules compared with ESCs. Notably, iPSCs and ESCs differentially express 17 modules that primarily function in transcription, metabo...

2013
Deepa Bhartiya Kenneth R. Boheler Pranela Rameshwar

Stem cells have captured the attention of both researchers and the public alike because of the promise of tissue regeneration, drug screening, and organogenesis. Stem cells are broadly classified as embryonic or adult with differentiation capacities ranging from pluripotent and multipotent to unipotent. In general, pluripotent stem cells are ascribed to cells derived from the inner cell mass of...

2012
Thekkeparambil Chandrabose Srijaya Padmaja Jayaprasad Pradeep Rosnah Binti Zain Sabri Musa Noor Hayaty Abu Kasim Vijayendran Govindasamy

Induced pluripotent stem cell-based therapy for treating genetic disorders has become an interesting field of research in recent years. However, there is a paucity of information regarding the applicability of induced pluripotent stem cells in dental research. Recent advances in the use of induced pluripotent stem cells have the potential for developing disease-specific iPSC lines in vitro from...

2015
Hiroaki Tateno Yasuko Onuma Yuzuru Ito Fumi Minoshima Sayoko Saito Madoka Shimizu Yasuhiko Aiki Makoto Asashima Jun Hirabayashi

The application of stem-cell-based therapies in regenerative medicine is hindered by the tumorigenic potential of residual human pluripotent stem cells. Previously, we identified a human pluripotent stem-cell-specific lectin probe, called rBC2LCN, by comprehensive glycome analysis using high-density lectin microarrays. Here we developed a recombinant lectin-toxin fusion protein of rBC2LCN with ...

2015
Yasuko Onuma Kumiko Higuchi Yasuhiko Aiki Yujing Shu Masahiro Asada Makoto Asashima Masashi Suzuki Toru Imamura Yuzuru Ito

Fibroblast growth factors (FGFs) are essential for maintaining self-renewal in human embryonic stem cells and induced pluripotent stem cells. Recombinant basic FGF (bFGF or FGF2) is conventionally used to culture pluripotent stem cells; however, because of the instability of bFGF, repeated addition of fresh bFGF into the culture medium is required in order to maintain its concentration. In this...

Journal: :Reproductive biomedicine online 2009
Hans-Werner Denker

Recent developments in research on embryonic stem cells and induced pluripotent stem cells suggest that potentiality of cells should be a new focus in stem cell research ethics and policy. Successful reconstitution of viable embryos from induced pluripotent stem cells using tetraploid complementation has been reported and indicates a way for direct cloning of individuals from these cells. This ...

2016
Mikko Konki Kalyan Pasumarthy Maia Malonzo Annele Sainio Cristina Valensisi Mirva Söderström Maheswara Reddy Emani Aki Stubb Elisa Närvä Bishwa Ghimire Asta Laiho Hannu Järveläinen Riitta Lahesmaa Harri Lähdesmäki R. David Hawkins Riikka J. Lund

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key...

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