The basis for Sustainable PLM is enabling Intelligent Products to communicate between themselves and with other systems in order to reduce CO2 emissions, energy usage and environmental damage. This type of communication between Intelligent Products and other information systems with the objective of reducing environmental impacts is an example of closed-loop product lifecycle management. The ob...

Competitive success of manufacturing firms is by and large determined by the success of the products they introduce to the market. This is why companies continuously try to improve the efficacy of their product realization process. Product Lifecycle Management (PLM) is a business solution which aims to streamline the flow of information about the product and related processes throughout the pro...

The advent of the product lifecycle management (PLM) system provides a Web-based IT platform that streamlines new product development (NPD) related processes by closely integrating the project team and the broader organization. However, there is a lack of systematic research on the use of PLM for better NPD management. The adaptation process for new technology is not yet well understood. This s...

Phospholemman (PLM) or FXYD1 is a major cardiac myocyte phosphorylation target upon adrenergic stimulation. Prior immunoprecipitation and functional studies suggest that phospholemman associates with the Na/K-pump (NKA) and mediates adrenergic Na/K-pump regulation. Here, we tested whether the NKA-PLM interaction is close enough to allow fluorescence resonance energy transfer (FRET) between cyan...

Sympathetic stimulation enhances cardiac contractility by stimulating β-adrenergic signaling and protein kinase A (PKA). Recently, phospholemman (PLM) has emerged as an important PKA substrate capable of regulating cytosolic Ca(2+) transients. However, it remains unclear how PLM contributes to β-adrenergic inotropy. Here we developed a computational model to clarify PLM's role in the β-adrenerg...

Phoslactomycins (PLMs), exemplified by PLM B (Figure 1), are a unique class of antitumor, antiviral, and antifungal polyketide natural products.1,2 The antitumor activity of PLMs is attributed to a potent and selective inhibition of protein Ser/Thr phosphatase 2A (PP2A).3 The PLM biosynthetic gene cluster from Streptomyces sp. HK803 has been cloned and sequenced.4 The PLM polyketide synthase (P...

This paper outlines a theoretical model, called the Pattern Lattice Model (PLM) of human linguistic knowledge and performance, and presents a simple implementation of this model. Any expressions found in a natural language L are structured in some ways, and linguists are willing to assume that those expressions are the products of what they call the grammar of L. In contrast, the PLM embodies a...