Nanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reported for nano drug delivery systems for intravenous administration, however very little is known about the effects of orally administered nanoparticles. Furthermore, the development of nanoparticulate syst...

Nanoparticles of biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) are widely used as drug delivery systems for the administration of biomolecules like proteins. The purpose of this work is to validate a novel formulation method by a phase separation phenomenon using the non-toxic solvent glycofurol (GF) in order to encapsulate proteins into PLGA nanoparticle...

This study investigates the effect of some formulation variables on particulate characteristics of poly (DL-lactide-co-glycolide) (PLGA) copolymer nanoparticles by applying 2(3) factorial design and response surface methodology (RSM). Nanoparticles were prepared by solvent displacement technique. Initially, appropriate formulation factors for elaboration of polymeric particles were selected by ...

Polymeric microparticles with covalently attached biotin are proposed as versatile targeting vehicles for drug delivery. The proposed microparticles made of 85/15 poly (lactic-co-glycolic acid) (PLGA) will have biotin available on the outside of the particle for the further attachment with an avidin group. Taking advantage of biotin's high affinity for avidin, and avidin's well-known chemistry,...

Abstract Promising cytotoxic (CD8 +) T cell-based cancer therapies have invigorated recent efforts to develop highly tunable, robust, and cost-effective artificial antigen presenting cells (aAPCs) for cell stimulation both ex vivoand in vivo. Natural APCs, such as dendritic (DCs), can be licensed deliver optimal activation signals (peptide-MHC S1, costimulatory S2, cytokine S3) CD8 +T with CD4 ...

The objective of this study was to prepare PLGA nanoparticles of Carvedilol that will improve the bioavailability of Carvedilol and sustain the release to reduce the initial hypotensive peak and to prolong the antihypertensive effect of the drug. Carvedilol encapsulated by Nanoprecipitation method using PLGA and Pluronic F-68.Prepared nanoparticles were examined for physicochemical characterist...

AbstractThe aim of the present study was to formulate poly (lactide-co-glycolide) (PLGA) nanoparticles loaded with 18-β-glycyrrhetinic acid (GLA) with appropriate physicochemical properties and antimicrobial activity. GLA loaded PLGA nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacterial activity of the developed nanopartic...

Lysozyme, as a model protein, was precipitated through the formation of protein-Zn complex to micronize for subsequent encapsulation within poly (lactic-co-glycolic acid) (PLGA) microspheres. Various parameters, including pH, type and concentration of added salts and protein concentration, were modified to optimize the yield of protein complexation and precipitation. The resulting protein parti...

Polymeric particles and liposomes are efficient tools to overcome the low immunogenicity of subunit vaccines. The aim of the present study was formulation and optimization of a new cationic lipid-modified PLGA nanoparticles (NPs) as a delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein. The cationic lipid-modified PLGA NPs containing HspX/EsxS fusion protein were prepared us...