Leukocyte migration to sites of inflammation is a multistep process involving transient adhesion to the endothelium followed by cell surface-controlled proteolysis for transmigration through the vessel wall and chemotactic movement within tissues. One of the key players in this machinery appears to be the urokinase-type plasminogen activator (uPA)/uPA receptor system. The role of uPA and its re...

Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in skin wound healing. However, wound closure and epidermal re-epithelialization are significantly less impaired in uPA;tPA double-deficient mice than in Plg-deficient mice. Skin wounds in uPA;tPA-deficient mice treated with the broad-spectrum ma...

BACKGROUND The role of plasminogen system components in focal cerebral ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator inhibitor-1 or alpha2-antiplasmin (PAI-1(-/-) or alpha2-AP-/-). METHODS AND RESULTS FCI was produced by ligation of the left middle cerebral artery an...

PURPOSE The purpose of this study was to evaluate an application of poly(d,l-lactide-co-glycolide) (PLG) scaffold created by electrospinning in a rabbit rotator cuff defect model. METHODS Forty-two Japanese white rabbits were used in this study. Defects of the infraspinatus tendon were created, and the PLG scaffolds were implanted. Contralateral infraspinatus tendons were reattached without c...

The aim of the study was to determine the effects of levofloxacin on the phagocytic and intracellular killing functions of human neutrophils at different therapeutic concentrations and to investigate the possible differences between pure powder and pharmaceutical form of levofloxacin on the neutrophil functions. Neutrophils obtained from healthy volunteers were incubated with both pure powder a...

Protein ligands were conjugated to the surface of biodegradable microspheres. These microsphere-ligand conjugates were then used in two in vitro model systems to evaluate the effect of conjugated ligands on microsphere behavior. Microsphere retention in agarose columns was increased by ligands on the microsphere surface specific for receptors on the agarose matrix. In another experiment, conjug...

We used a polymerase chain reaction (PCR) strategy and restriction fragment polymorphism analysis to evaluate all 19 exons of the plasminogen (PLG) gene in a Japanese patient with congenital PLG deficiency and her family members. She presented with cerebral infarction. Sequence analysis following amplification of each exon and its flanking regions showed a single T to C transition in exon 14, w...

We show that a product of two Laguerre–Gaussian (pLG) beams can be expressed as finite superposition conventional LG with particular coefficients. Based on such an approach, explicit relationship is derived for the complex amplitude pLG in Fresnel diffraction zone. Two identical duet produce case “squared” Fourier-invariant beam, termed (LG)2 beam. For described by Laguerre polynomials azimutha...

Abstract Backgrounds L-carnitine decreases oxidation and inflammation by reducing the fatty acid in plasma using oxygen ATP synthesis. As such, knee osteoarthritis (KOA) can be improved apoptotic chondrocytes. This study was designed to compare effect of supplementation low-calorie diet on improving KOA among obese women. We further investigated L- carnitine improvement women low calorie diet. ...

Dieser Beitrag ist ursprünglich im Peter-Lang-Verlag erschienen (https://www.ingentaconnect.com/contentone/plg/jwf/2022/00000006/00000002/art00006)