In nitric-oxide synthases (NOSs), two flexible hinges connect the FMN domain to the rest of the enzyme and may guide its interactions with partner domains for electron transfer and catalysis. We investigated the role of the FMN-FAD/NADPH hinge in rat neuronal NOS (nNOS) by constructing mutants that either shortened or lengthened this hinge by 2, 4, and 6 residues. Shortening the hinge progressi...

This paper presents an optimization study of a lightweight hinge consisting of a thin walled tube made of carbon fiber reinforced plastic with two longitudinal slots. The slot geometry is parameterized in terms of slot length, width and end circle diameter. Previously developed numerical simulation techniques to analyze the folding and deployment of this kind of hinges are used to carry out a s...

This study presents a finite element (FE) model, the accuracy of which is verified by comparison between numerical and test results. The calibrated model used to investigate influence vertical arrangement masonry material infill walls on seismic performance reinforced concrete (RC) frames through pushover analysis time–history analysis. lateral capacity, interstorey drift ratio, plastic hinge d...

The most susceptible area of a structural member, where the inelastic rotation would take place, is plastic hinge. At this stage, flexural elements in particular achieve their maximal bending flexibility. This study uses finite element analysis (FEA) and experimental inquiry to analyze test effects carbon fiber mesh jacketing steel reinforcement at concrete beam’s hinge length subjected vertica...

Progressive collapse assessment of a reinforced concrete (RC) building designed only for gravity loads and lacking dedicated lateral load resisting system was carried out using the alternate path (ALP) method finite element (FEM) numerical model created in software SAP2000. Plastic hinge capacity members evaluated considering flexure (M), axial force (N) shear (V) interaction validated procedur...

To analyze the multidimensional elastic–plastic response of frame structure with magnetorheological (MR) dampers under strong seismic excitations, test MRD was performed, location matrix in derived, and calculation models without an were established based on three-segment variable stiffness beam. Taking a five-story reinforced concrete (RC) as example, developed by MATLAB software dynamic time ...

The main purpose of this paper was to use a combination of Energy-based design method and whale algorithm (WOA), hereinafter referred to as E-WOA, to optimize steel moment frames and improve the seismic performance. In E-WOA, by properly estimating the seismic input energy and determining the optimal mechanism for the structure, steel frames are designed based on the energy balance method; acco...

BACKGROUND AND AIM OF THE STUDY Most bileaflet mechanical heart valves (BMHVs) incorporate some retrograde flow through their hinge mechanism to prevent flow stasis and inhibit microthrombus formation. This reverse flow is characterized by high velocities and shear stresses, thereby promoting platelet activation and hemolysis inside the hinge region. In the present study, the thromboembolic pot...