INTRODUCTION Hyperhomocysteinemia is a coronary risk factor, but its pathophysiologic mechanism remains unclear. MATERIALS AND METHODS The importance of hyperhomocysteinemia in the pathogenesis of early myocardial infarction, was determined in case-control study of 127 men with a first early myocardial infarction <or=45 years and 150 age-matched male controls. We measured plasma concentration...

Harvest fluid concentrates (HFC's) from three human mam mary tumor cell lines (T47D, HS0578T, and MDA-MB-157), one nontumorigenic human mammary cell line (HBL-100), and one mouse mammary tumor cell line (MCG-T14) stimulated thymidine incorporation in confluent quiescent BALB/c 3T3 cells in a dose-dependent manner. HFC's from all of the cell lines also exhibited plasminogen activator activity. L...

We have investigated the fibrinolytic status of 56 patients with rheumatoid arthritis (RA). Plasma fibrinogen and plasminogen were significantly elevated. Levels of these two substrates, along with alpha 2 macroglobulin and antithrombin III correlated with disease activity. Plasminogen activator (PA) activity was decreased in patients with severe disease. Twelve patients were given stanozolol, ...

In parallel with the increased interest during the past decade in plasminogen activator involvement in fibrinolysis, tumorigenesis, inflammatory responses, and the expression of hormonal regulation, there has been a rising interest in sensitive and precise methods for the specific assay of plasminogen activator. Several assays for plasminogen activator employ a direct assay These are remarkably...

The discovery that tissue plasminogen activator can promote neuronal degeneration has uncovered a novel pathway leading to neuronal cell death and raises important issues concerning the use of tissue plasminogen activator as a thrombolytic therapy for stroke.

The effects of purified soluble fibrin and of fibrinogen fragments (fibrin mimic) on the activation of Lysplasminogen (i.e. plasminogen residues 77-790) to plasmin by streptokinase plasminogen activator complex and by tissue-type plasminogen activator were studied. Dissociation constants of both activators were estimated to lie in the range 90-160 nm (fibrin) and 16-60 nM (CNBr-cleavage fragmen...