Only turnover studies can reveal the mechanism behind an abnormal serum concentration of a given protein. Albumin, the major fraction of serum protein, is usually low when total serum protein is low and hence basic causes of hypoproteinaemia are much the same as those of hypoalbuminaemia: (1) increased catabolism which occurs in a variety of acute conditions such as acute infections, trauma inc...

Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling. Human serum albumin (HSA) and α1-acid glycoprotein (AGP) are two plasma proteins that bind a variety of endogenous and exogenous substances. The ligand binding mechanism of these two proteins is complex. Fatty...

The Gαq/phospholipase Cβ1 (PLCβ1) signaling system mediates calcium responses from hormones and neurotransmitters. While PLCβ1 functions on the plasma membrane, there is an atypical cytosolic population that binds Ago2 other proteins associated with stress granules preventing their aggregation. Activation of Gαq relocalizes to releasing bound proteins, promoting formation granules. Here, we hav...

Objective(s)The aim of this study was to evaluate plasma levels of nitric oxide (NO) and certain acute phase proteins(caeruloplasmin, transferrin, haptoglobin, C-reactive protein) in Nigerian subjects after short and prolonged exercises.Materials and MethodsA total of 57 subjects (34 males and 23 females) between ages of 19 and 45 years participated in this study and weredivided into three grou...

Mass spectrometry (MS) is one of the key technologies used in proteomics. The majority studies carried out using proteomics have focused on identifying proteins biological samples such as human plasma to pin down prognostic or diagnostic biomarkers associated with particular conditions diseases. This study aims quantify microbial (viral and bacterial) healthy plasma. MS data were searched again...

The concentrations of 25 plasma proteins were measured in 22 patients with membranous nephropathy. For some large proteins, the plasma concentrations were increased; there were also large proteins with low plasma concentrations, but small or medium-sized proteins showed uniformly lower plasma concentration than the controls. Plasma colloid osmotic pressure (pi) and viscosity (eta) were not inte...

Blood plasma (BP) is a borderline non-Newtonian fluid. Few studies have characterized the rheology of BP and even less focused on understanding its subtle viscoelastic traits, which were only somewhat recently acknowledged. We use passive microrheology to measure bulk response human samples under shear at body ambient temperatures. Evidence subdiffusive behavior in mean-squared displacement obs...

the objective of this study was to evaluate kinetics and the residual decline of tylosin in milk and plasma of lactating najdi ewes following single intramuscular injection of tylosin at the dose of 10 mg/kg. blood and milk samples were collected from the ewes before and at different time intervals after treatment. tylosin concentrations were determined by microbiological agar plate assay using...

background: in this study we have prepared the iga solution from normal human plasma using plasma fractionation and ion exchange chromatography. materials and methods: using fractionation of plasma with cold ethanol (starting with 8% ethanol), fraction iii was prepared as a suitable source for iga preparation. then it was treated with caprylic acid for separation of impurities. for enrichment o...