Abstract We developed a localized plasma-enhanced chemical vapor deposition (PE-CVD) technique to deposit silicon oxide with sub-micrometer width on substrate using an atmospheric pressure plasma jet (APPJ) irradiated from nanopipette nozzle. To realize fine material deposition, hexamethyldisiloxane (HMDSO) was blown into the helium APPJ aperture of nanpopipette length limited size nanopipette....

AIMS We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species. METHODS AND RESULTS Screening of the fasted plasma lipidome was performed by top-down shotgun a...

Background and Purpose—Glutathione (GSH) appears to have marked antioxidant activities and therefore may prevent cardiovascular disease (CVD). However, there are very few reports on this subject. In a community-based case–control study, we tested the hypothesis that low levels of plasma GSH are closely associated with CVD and its clinical types. Methods—The association between fasting plasma to...

CONTEXT C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD). OBJECTIVE To assess whether polymorphisms in the CRP gene are associated with plasma CRP, carotid intima-media thickness (CIMT), and CVD events. DESIGN, SETTING, AND PARTICIPANTS In the prospective, population-based Cardiovascular Health Study, 4 tag single-n...

CONTEXT There is a need for increased knowledge about endogenous sex hormone levels and clinical outcomes of risk/benefit. Immunoassays have poor specificity to reliably measure low steroid concentrations in elderly. OBJECTIVE The objective of the study was to evaluate plasma steroid concentrations with regard to prevalent cardiovascular disease (CVD) in elderly, using mass spectrometry. SE...

OBJECTIVE Our objective was to examine associations among plasma homocysteine concentrations (tHcy), the tHcy-cofactors (folate, vitamins B6 and B12), and multiple domains of cognitive performance, with statistical adjustment for possible confounds, including cardiovascular disease risk factors (CVD-RF) and cardiovascular disease (CVD). METHODS Subjects were 812 participants (58% women) of th...

OBJECTIVES To prospectively examine the association of plasma γ' fibrinogen with the incidence of multiple cardiovascular disease (CVD) end points, independent of established CVD risk factors, total fibrinogen, and other inflammatory markers. APPROACH AND RESULTS The Atherosclerosis Risk in Communities (ARIC) study measured γ' fibrinogen by enzyme-linked immunosorbent assay in stored plasma s...

OBJECTIVE Annexin A5 (ANXA5) has been suggested to possess antiatherogenic properties. We investigated whether ANXA5 genetic variations and plasma ANXA5 levels were associated with carotid atherosclerosis and contributed to cardiovascular disease (CVD) risk in patients with familial hypercholesterolemia (FH). METHODS We sequenced the promoter region and exon 2 of ANXA5 in 284 FH patients from...