CONTEXT Metabolic syndrome shows clustered metabolic abnormalities with major roles for insulin resistance and obesity. Ghrelin is a gastric hormone whose total plasma concentration (T-Ghr) is associated positively with insulin sensitivity and is reduced in obesity. Ghrelin circulates in acylated (A-Ghr) and desacylated (D-Ghr) forms, but their potential differential associations with insulin r...

Objective(s):Consumption of high-fat foods is one of the major causes of obesity. Physical exercise is a strategy used to counteract obesity. The aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (HFD) on appetite-regulating hormones in rat plasma. Materials and Methods:Twenty eight male Wistar rats were randomly divided into four groups: Contro...

BACKGROUND The risk of different cancers seems to be associated with obesity. Moreover, low ghrelin levels observed in obese people may be implicated in cancer development and progression. The aim of this study was to examine the direct effects of both forms of ghrelin (acylated and unacylated) and ghrelin receptor type 1a antagonist (D-Lys-GHRP-6) on the growth of murine colon cancer MC38 and ...

CONTEXT Acute energy deficits imposed by food restriction increase appetite and energy intake; however, these outcomes remain unchanged when energy deficits are imposed by exercise. OBJECTIVE Our objective was to determine the potential role of acylated ghrelin and peptide YY(3-36) (PYY(3-36)) in mediating appetite and energy intake responses to identical energy deficits imposed by food restr...

Background. High-intensity interval training (HIIT) may affect acylated ghrelin (AG) through changes in body composition. Objectives. The present study was designed to investigate and compare the effects of two different orders of wrestling-based HIIT on AG levels and body composition in highly trained wrestlers. Methods. Forty-two male wrestlers (aged 16–21 years) were randomly assigned to o...

Introduction: Ghrelin is a peptide hormone secreted from the stomach with both endocrine and paracrine effects. Ghrelin and its mRNA as well as growth hormone (GH) secretagogue receptor mRNAs are expressed in the pancreas and islet cells and regulate insulin release. Also the immounoreactivity of ghrelin is proved to be high in the hypothalamus and parts of the brain responsible for the re...

Since its discovery in 1999, ghrelin has been implicated in a multiplicity of physiological activities. Most notably, ghrelin has an important influence on energy metabolism and after the identification of its potent appetite stimulating effects ghrelin has been termed the 'hunger hormone'. Exercise is a stimulus which has a significant impact on energy homeostasis and consequently a substantia...