Homeobox genes are a group of transcription factors that play important roles in development (for a review see Bürglin, 1995; Gehring et al., 1994). One particular class, the POU class of homeobox genes, was first defined by the transcription factors Pit1, Oct1, Oct2, and the Caenorhabditis elegans developmental control gene unc-86 (Herr et al., 1988). Since the initial identification of the PO...

Genetic suppression of insulin/insulin-like growth factor signaling (IIS) can extend longevity in worms, insects, and mammals. In laboratory mice, mutations with the greatest, most consistent, and best documented positive impact on lifespan are those that disrupt growth hormone (GH) release or actions. These mutations lead to major alterations in IIS but also have a variety of effects that are ...

Clinical trials evaluating negative pressure wound therapy (NPWT) as a treatment for ulcer (PU) have been inconclusive. The objective of this research was to evaluate the effect NPWT on length stay (LOS), charges, and mortality PU patients. data collected over 4-year period from large medical institution in OMNY Health System Database were used identify adult Patients excluded if also diagnosed...