The present scientific peer review describes on novel natural cyclobutane characterization of this alkaloid showed that it an efficient bioavailability enhancer for different anti-cancer, anti-depressant, anti-apoptotic, anti extraction, quantification and applications of piperine we substantial knowledge to scientific world to develop industries.

Vitiligo is a depigmentation disorder; Reactive Oxygen Species (ROS) plays a major role in the development of depigmentation. Monoamine oxidase-A(MAO-A) enzyme is one of the reasons in producing ROS by metabolizing norepinephrine which found to be high level in vitiligo patients. Inhibiting MAO-A enzyme prevents further depigmentation. Clinical studies proved that the isoquinoline alkaloids hav...

Objective: Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. 18 β-Glycyrrhitic acid (GA) is chemically pentacyclic triterpenoid which possess powerful antiinflammatory action. The present study was designed to formulate GA reservoir-type transdermal patches using piperine as bioenhancer. Method: Transdermal Patch of GA was prepared...

Abstract – HCTN7. Plasma cholesterol level plays an important role in atherosclerosis and cardiovascular diseases. Piperine, alkaloid form of black pepper is known to reduce uptake. In this paper, piperine-loaded chitosan nanoparticles (CTS-PIP NPs) were prepared by ionic gelation method. Molecular interactions among the components confirmed FT-IR spectroscopy. Transmission electron microscopy ...

Breast cancer is the most common malignancy in women worldwide. associated with a high mortality rate and health-related economic burden. patients have low 5-year life expectancy when diagnosed at advanced stages. Besides, emergence of chemoresistance breast has led to an intense search for alternative anticancer agents. One potential compounds Piperine. Several studies had found that Piperine ...

Background: Piperine is an alkaloid present in black pepper. It causes increase diameter of Graafian follicles when given to adult female albino rats thus leading decreased fertility. Aim: To assess the harmful effects piperine on ovaries follicles. Study design: Experimental Study. Place and duration study: Anatomy Department, Shaikh Zayed PGMI, Lahore from 1st August 2013 31st January 2014. M...

BACKGROUND Obesity is associated with low-grade inflammation and impaired immune response. Caloric restriction (CR) has been shown to inhibit inflammatory response and enhance cell-mediated immune function. Curcumin, the bioactive phenolic component of turmeric spice, is proposed to have anti-obesity and anti-inflammation properties while piperine, another bioactive phenolic compound present in...

Background The overall goals for treatment of Tuberculosis (TB) are to cure individual patient and to minimize the transmission of Mycobacterium tuberculosis. At the time of study conduction, the standard treatment for newly diagnosed tuberculosis patients consisted of an intensive phase for two months with four drugs (HRZE), followed by continuation phase for four months with two drugs (HR). R...

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in an...

Aflatoxins are mycotoxins that have important toxic effects on human and animal health, even if consumed at low doses. The oral administration of piperine (1.12 mg/kg) during 23 days in rats seemingly interfered with the toxicity of aflatoxins, decreasing hepatic injuries and the leukocyte depletion in experimentally intoxicated animals.