نتایج جستجو برای: piperacillin

تعداد نتایج: 2563  

Journal: :Pharmacotherapy 2002
Edward M Grant Joseph L Kuti David P Nicolau Charles Nightingale Richard Quintiliani

STUDY OBJECTIVE To compare continuous versus intermittent administration of piperacillin-tazobactam with regard to clinical, microbiologic, and economic outcomes. DESIGN Prospective, open-label controlled study SETTING Community teaching hospital. PATIENTS Ninety-eight hospitalized patients prescribed piperacillin-tazobactam. INTERVENTION Substitutions were implemented so that 47 patien...

Journal: :Antimicrobial agents and chemotherapy 2004
Nina Singh Asia Obman Shahid Husain Sherrie Aspinall Sue Mietzner Janet E Stout

The possible reactivities of commonly used antibiotics of fungal, nonfungal, and nonmicrobial or synthetic sources with the Platelia Aspergillus galactomannan assay were assessed. For drugs that tested positive, the minimal concentration of the antibiotic in serum that yielded a positive test (index, >0.5) was determined. At undiluted concentrations, piperacillin and multiple lots of piperacill...

Journal: :Antimicrobial agents and chemotherapy 1983
H Konishi M Goto Y Nakamoto I Yamamoto H Yamashina

The in vitro and in vivo inactivation of tobramycin by carbenicillin, ticarcillin, or piperacillin was investigated by the enzyme immunoassay method in clinically employed dosages. After the addition of an 80-mg dose of tobramycin to 4- to 5-g doses of a penicillin in 100 ml of 0.9% saline or distilled water, the degradation profile of tobramycin appeared to follow a biexponential pattern of de...

2017
Varun Kumar Sandeep Khosla Monica Stancu

Imipenem-cilastatin and piperacillin-tazobactam are two antibiotics with broad antimicrobial coverage. Besides the many well established adverse effects of these drugs, there have been few case reports of hypokalemia. Here we present an interesting case of resistant hypokalemia caused by these drugs leading to Torsades de Pointes which has never been reported in the past. Hypokalemia resolved w...

2016
Yong Kyun Kim Jin Ah Jung Hyang Ki Choi In Gyu Bae Won Suk Choi Jian Hur Sung Joon Jin Shin Woo Kim Ki Tae Kwon Sang Rok Lee Jae Gook Shin Sungmin Kiem

BACKGROUND For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on the patients' characteristics, including race. The aim of this study was to investigate the population pharmacokinetic (PK) profiles of piperacillin and tazobactam in Korean patients with acute infections. MATERIALS AND METHODS At least four consecutive 2/0.25 g or 4/0.5 g doses...

Journal: :Antimicrobial agents and chemotherapy 2013
F Docobo-Pérez L López-Cerero R López-Rojas P Egea J Domínguez-Herrera J Rodríguez-Baño A Pascual J Pachón

Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems are among the recommended empirical treatments for health care-associated complicated intra-abdominal infections. In contrast to amoxicillin-clavulanate, both have reduced in vitro activity in the presence of high concentrations of extended-spectrum β-lactamase (ESBL)-produ...

2013
T. W. Felton J. Goodwin L. O'Connor A. Sharp L. Gregson J. Livermore S. J. Howard M. N. Neely W. W. Hope

Management of nosocomial pneumonia is frequently complicated by bacterial resistance. Extended infusions of beta-lactams are increasingly being used to improve clinical outcomes. However, the impact of this strategy on the emergence of antimicrobial resistance is not known. A hollow-fiber infection model with Pseudomonas aeruginosa (PAO1) was used. Pharmacokinetic (PK) profiles of piperacillin-...

Journal: :Mikrobiyoloji bulteni 2006
Pinar Zarakolu Gülşen Hasçelik Serhat Unal

Antimicrobial susceptibility patterns of Gram negative pathogens (n: 699) isolated from nosocomial infections in Hacettepe University Adult Hospital included in MYSTIC programme between 2000-2004 were determined by Etest (AB BIODISK, Solna, Sweden) using CLSI criteria. Of the total Escherichia coli (n: 179), Klebsiella pneumoniae (n: 168), Pseudomonas aeruginosa (n: 179) and Acinetobacter bauma...

Journal: :Antimicrobial agents and chemotherapy 2005
F J Legat R Krause P Zenahlik C Hoffmann S Scholz W Salmhofer J Tscherpel T Tscherpel H Kerl P Dittrich

We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.

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