BACKGROUND Ocular adnexal IgG4-related sclerosing disease (IgG4-SD) has been categorized as a novel disease entity. It is characterized by stromal sclerosis and an infiltration of mass-forming lymphoplasmic cells containing many IgG4-positive plasma cells. Although ocular adnexal tissue involvement has been increasingly reported, a focal nodular sub-brow mass is not typical in an IgG4-SD presen...

With some simplifications, computational protein folding can be understood as an optimization problem of a potential energy function on a variable space consisting of all conformation for a given protein molecule. It is well known that realistic energy potentials are very "rough" functions, when expressed in the standard variables, and the folding trajectories can be easily trapped in multiple ...

Multiple pilomatricomas are rare. In the literature, they have been associated with many conditions, although the most common association is with myotonic dystrophy. We present a new association not previously described in the literature, observed in a 28-year-old male with three pilomatricomas, who had been diagnosed with seminoma 15 months before the current diagnosis of multiple pilomatricom...

The influence of extracytoplasmic proteases on the resistance of Escherichia coli to the antimicrobial peptide protamine was investigated by testing strains with deletions in the protease genes degP, ptr, and ompT. Only DeltaompT strains were hypersusceptible to protamine. This effect was abolished by plasmids carrying ompT. Both at low and at high Mg2+ concentrations, ompT+ strains cleared pro...

Pilomatricoma or benign calcifying epithelioma of Malherbe is a benign appendageal tumour originating from primitive cells of the hair matrix. Perforation (transepidermal elimination), bullous or anetodermic cutaneous changes overlying pilomatricomas are rare events. In this report, we describe a case of pilomatricoma with bullous appearance or secondary anetoderma. The tumour was totally excis...