Sharma and Rajapurkar (~) while studying the actions of adrenergic neurone blocking drugs on intestinal peristalsis observed that bretyliurn and xylocholine in bigger doses produced a stimulant response on the longitudinal moveme-nts of guinea pig ileum where as guanethidine had no stimulant action (unreported observations). Those observations are in consonance witb tbe observations of Boura an...

A test system based on the use of ion exchanges, gel filtration on Sephadex and extraction with organic solvents is described. This system provides information on the stability, molecular size, charge, and polarity of the pharmacologically active compounds in the aqueous plant extracts. Knowledge of these properties permitted the development of an isolation method for a glucose present in the a...

When cytoplasmic extracts of the myenteric plexus of guinea pig ileum are submitted to centrifugal density gradient separation in a zonal rotor, conditions which separate storage particles containing substance P, somatostatin and VIP from each other, PHI copurifies with VIP. The two immunoreactivities cannot be separated by particle exclusion chromatography, which depends on size rather than de...

Interstitial cells of Cajal (ICC) in the guinea pig intestine, identified by the tyrosine kinase receptor, c-Kit, have been shown with immunohistochemistry to express nucleotide P2X2 and P2X5 receptors. P2X5 receptors have also been demonstrated on interstitial cells in the mouse ileum. It is speculated that release of ATP from enteric nerves, enteric glial cells or from contracting smooth musc...