Background: Gestational trophoblastic neoplasia (GTN) originates from placental trophoblast and is a highly chemosensitive and curable gynecologic malignancy. The present study was conducted to evaluate the effectiveness and safety of EMA/EP (etoposide, methotrexate, actinomycin-D, etoposide, and cisplatin) regimen in the treatment of high-risk GTN as well as patients’ outcome.  &nb...

Neonate ruminants possess little cell-wall and starch degrading enzyme activity. Importantly, early establishment of fibrolytic, amylolytic, and proteolytic capacities is influential for the early expansion of the reticulorumen epithelia. Such an early development in reticulorumen fermentation will enable a timely hepatic adaptation to volatile fatty acids assimilation. The early nutrient relea...

It remains a challenge to prepare flame-retardant composites via the addition of low content flame retardant. In this work, novel DOPO-functionalized reduced graphene oxide hybrid (DOPO-M-rGO) system was synthesized for epoxy resin (EP). The phosphorus-nitrogen-reduced ternary synergistic effect provided DOPO-M-rGO with high flame-resistance efficiency in EP; thus, EP-based composite exhibited ...

Background: There has been little research on electronic prescribing (EP) in Middle Eastern countries. This is in part due to the slow implementation of electronic health records [EHR] integrated with EP. Electronic prescribing is associated with a considerable reduction in medication errors compared to handwritten prescriptions. Objective: This paper reviews the relevant literature on handwrit...

A large deviation technique is used to calculate the microcanonical entropy function s(v,m) of the mean-field φ4-model as a function of the potential energy v and the magnetization m. As in the canonical ensemble, a continuous phase transition is found. An analytical expression is obtained for the critical energy vc(J) as a function of the coupling parameter J .

Each rational investment decision, also that made by client with regard to the Business Software Systems (BSS) Development and Enhancement Projects (D&EP), should meet two measurable criteria: of effectiveness and of economic efficiency. In the case of BSS D&EP the assumption concerning measurability of these criteria is often treated as controversial. Thus the paper aims at proving from theore...

The purpose of this paper is to investigate the chemical composition, the polymerization ability and the abrasion resistance of two brands (Isosit, Plastique) of thermo-setting resin for crown and bridge. 1. Isosit (Is) contained approximately 55 per cent of MFR type filler and 45 per cent of a comonomer (urethane dimethacrylate, 1, 3 butane dimethacrylate and 1, 10 decamethylene dimethacrylate...

We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR) specific for vascular endothelial growth factor receptor 2 (VEGFR2), demonstrated significant antitumor effects in various murine solid tumor models. In the present study, we prepared anti-VEGFR2 CAR-T cells by CAR-coding mRNA electroporation (mRNA-EP) and analyzed...