Cancer chemotherapy has been practised from time immemorial and Rhazes, a Baghdad surgeon, introduced chemistry into “physic” in the ninth century A.D. In 1894 W. B. Coley used the toxins of streptococcus pyogenes and bacillus prodigiosus to treat twelve patients with inoperable bone sarcoma, and disappearance of the tumour occurred in three cases. Johnston (1962), in a carefully controlled tri...