oxidative stress is involved in the pathogenesis of asthma. paraoxonase 1 (pon1) and arylesterase are esterase enzymes displaying antioxidant characteristics. pon1 activity varies widely among individuals and ethnic groups, partly related to polymorphisms. the aim of this study was to determine the activities of pon1 and arylesterase including the phenotype distribution of pon1 in asthmatic pat...

objective brain abscesses represent organized foci of suppuration within the parenchyma. here we report a 3 month-old girl with a very huge complicated cerebral abscess, and the course of treatment given. the patient's recovery was excellent. the follow up mri showed only subtle porencephalic changes as the only parenchymal sequelae, which may be due to cns plasticity in infants.

migraine is a primary headache which is very common in the society. although it is usually starts in a salient point in life span of an individual diagnostically, the repetition of acute stress response such as sleep abnormalities, anxiety, and depression are not new in this population. therefore, they have had almost a long diary of these abnormalities. in order to understand the role/s of str...

Abstract AIMS The immense cellular plasticity of glioblastoma is a barrier to successful therapy. N6-methyladenosine (m6A) methylation RNA increasingly recognised as key driver differentiation. Crucially, it reversible and dynamic modification that alters phenotype via the regulation mRNA metabolism. We hypothesise m6A mediates plasticity, regulating transcriptional networks thus influencing ad...

Abstract Background S100A4, a small calcium binding protein, plays an important role in vascular smooth muscle cell (SMC) phenotypic switch but its implication atherosclerotic plaque development and particularly SMC plasticity is not clear yet. By neutralizing S100A4 using monoclonal antibody, we have previously shown reduction overall burden. However, this strategy did distinguish the differen...

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology II (PD42)1 Sep 2021PD42-11 THE SWITCHING PHENOTYPE AND INTRATUMOR PLASTICITY IN BLADDER CARCINOMA: A MONO-INSTITUTIONAL ANALYSIS OF 211 MUSCLE-INVASIVE CARCINOMA WITH CONSIDERATIONS FOR THERAPY Piergiuseppe Colombo, Miriam Cieri, Paolo Zucali, Camilla De Carlo, Grazia Elefante, Rodolfo Hurle, Massimo Lazzeri, Fede...

Introduction Responses of endothelial cells to circulating substances (hormones, growth factors, drugs, agonists, toxic reagents etc) are a function of the particular phenotype of a particular cell(s) at a particular period of time. The endothelial phenotype is determined by 2 distinct components – (i) an intrinsic phenotype imprinted genetically during development that defines the essential id...

Synaptic vesicle 2 (SV2) proteins, critical for proper nervous system function, are implicated in human epilepsy, yet little is known about their function. We demonstrate, using direct approaches, that loss of the major SV2 isoform in a central nervous system nerve terminal is associated with an elevation in both resting and evoked presynaptic Ca(2+) signals. This increase is essential for the ...

Phenotypic plasticity plays a key role in modulating how environmental variation influences population dynamics, but we have only rudimentary understanding of how plasticity interacts with the magnitude and predictability of environmental variation to affect population dynamics and persistence. We developed a stochastic individual-based model, in which phenotypes could respond to a temporally f...