The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The (equimolar ratio) and tromethamine were prepared solvent co-evaporation method. solid-state properties resulting powder characterized X-ray diffraction, DSC thermal analysis, FT–IR spectroscopy, solubility, in vitro rate. crystal structure was determined single-crystal diffr...

the object of this work is solubility correlation and prediction of co2 and h2s in various aqueous alkanolamines using the electrolyte cubic square-well equation of state (ecsw eos) [haghtalab, a.,mazloumi, s. h., (2009a), fluid phase equilib.,285,96-104]. the eeos systematically is applied to describe the solubility of acid gases in various alkanolamine solutions, including mdea, mea, dea, amp...

Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution. The objective of the present work was to prepare, formulate and evaluate the piroxicam cocrystal by screening various coformers. Methods: Cocrystals of piroxicam were prepared by dry grinding method. The melting point and solubility of ...

The dissolution of invaded gas in the drilling fluid during results an increase invasion concealment. This is great significance for development acid reservoirs to determine solubility change and multiphase flow law annulus after by natural with high CO 2 content. In this study, control equations gas–liquid are established considering influence solubility. For prediction solubility, interaction...

Different samples of purified tobacco mosaic virus show a relatively wide variation in solubility in ammonium sulfate solution. This variation and the type of solubility curve obtained in the presence of varying amounts of solid phase show that the purified virus whether isolated by mild treatment with ammonium sulfate or by ultracentrifugation is not a homogeneous chemical substance but contai...

This in vitro investigation of the behavior of two types of calcium phosphate glass ceramics on the basis of phosphates of biogenic or synthetic origin prepared from initial mixtures with different particle size has revealed that some different factors affect the behavior, namely the phase composition of composite, fraction of open porosity, and average diameter of pore channels. It was establi...

A one-pot method for the preparation of benzoyl metronidazole was achieved by using N,N'-carbonyldiimidazole as a coupling reagent. Moreover, it was found that the byproduct imidazole as the catalyst promoted the reaction. In addition, the β-cyclodextrin solubilization of benzoyl metronidazole was investigated by phase-solubility method. The phase-solubility studies indicated that the solubilit...

solubility of hydrocarbons in water is important due to ecological concerns and new restrictions on the existence of organic pollutants in water streams. also, the creation of a thermodynamic model has required an advanced study of the phase equilibrium between water (as a basis for the widest spread muds and amines) and gas hydrocarbon phases in wide temperature and pressure ranges. therefore,...