نتایج جستجو برای: pharmacologic model

تعداد نتایج: 2122181  

1999
John M. Kane Christoph U. Correll

The pharmacologic treatment of schizophrenia remains a critical component in the short- and long-term management of this disease. Considerable progress has been made in delineating different domains of this illness, ranging from positive and negative symptoms to cognitive dysfunction and psychosocial vulnerabilities. Increasingly, treatments are being studied in relation to a variety of differe...

2014
Jianfei Yang Mohamed Boudjelal Mark Sundrud Shomir Ghosh Lisa A. Orband-Miller Ashley Barnes Erkan Baloglu Mercedes Lobera Thaddeus Carlson Jill Skepner Radha Ramesh Mark Trocha Darby Schmidt Jonathan Hill

IL-17–producing CD4 + Th17 cells, CD8 + Tc17 cells, and gd T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORgt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel, potent, and selective RORgt inverse agonist (TMP778), and its inactive diastereomer (TMP776). This chemistry, for the first time to our knowledge,...

Journal: :Epilepsia 2001
H Kupferberg

The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. These models can be either in vivo or in vitro, mechanism specific, mechanism independent, or seizure specific. To be predictive of therapeutic activity in patients, the models should approximate the events that precipitate seizures in humans. Model validation is defined by deter...

حتم خانی, شیما, صعودی, رضا, مدرس زاده, مهدی,

  Background: To present an overview of the pharmacologic treatment of pseudophakic macular edema.   Methods: A systematic review of the currently accepted pharmacologic treatments for pseudophakic macular edema. Main outcome parameters include visual acuity and central macular thickness as determined by ocular coherence tomography. Articles retrieved by Pubmed search using keywords pseudophaki...

صعودی, رضا, مدرس زاده, سید مهدی , ملکی, آرش, میرزاجانی, حورا, نظری, حسین,

  Introduction : The vitreoretinal interface is involved in a wide range of vitreoretinal disorders and separation of the posterior vitreous face from the retinal surface is an essential part of vitrectomy surgeries. A diverse range of enzymatic and non-enzymatic agents are being studied as an adjunct before or during vitrectomy to facilitate the induction of posterior vitreous detachment. Ther...

Journal: :Comprehensive psychiatry 1983
L B Guttmacher D L Murphy T R Insel

T HE UBIQUITY OF ANXIETY is reflected by the fact that 18% of Americans had an anxiolytic prescribed in 1972, and 6% had more than 2 mo of continuous exposure to a benzodiazepine. Much of the literature on pharmacologic models of anxiety, especially that relating to catecholamines, is quite old and offers a fascinating historical perspective on the modern development of biologic psychiatry. Thi...

2013
James s. Kalus James S. Kalus

James S. Kalus, Pharm.D., BCPS (AQ-Cardiology), is Senior Manager, Patient Care Services, Department of Pharmacy Services, Henry Ford Hospital, Detroit, MI. Address correspondence to Dr. Kalus at Henry Ford Hospital, Department of Pharmacy Services, 2799 West Grand Boulevard, Detroit, MI 48202 ([email protected]). Based on the proceedings of a symposium held December 3, 2012, during the 47th ASH...

Journal: :American family physician 2011
Allen R Last Jonathan D Ference Julianne Falleroni

Pharmacologic treatment of hyperlipidemia in conjunction with therapeutic lifestyle changes can be used for both primary and secondary prevention of cardiovascular disease. Statins have the most convincing data for primary prevention, especially for higher risk patients. Therefore, risk stratification is essential. Statin therapy is also recommended for secondary prevention in all patients with...

Journal: :The Journal of infectious diseases 2014
Lien Dejager Sofie Vandevyver Marlies Ballegeer Elien Van Wonterghem Ling-Ling An Jeffrey Riggs Roland Kolbeck Claude Libert

Current research on new therapeutic strategies for sepsis uses different animal models, such as the lipopolysaccharide-induced endotoxemia model and the cecal ligation and puncture (CLP) peritonitis model. By using genetic and pharmacologic inhibition of the type I interferon (IFN) receptor (IFNAR1), we show that type I IFN signaling plays a detrimental role in these sepsis models. Mortality af...

Journal: :Canadian family physician Medecin de famille canadien 2008
Jason Schmelzle Walter W Rosser Richard Birtwhistle

OBJECTIVE To review the evidence on the efficacy and safety of pharmacologic and nonpharmacologic therapies for smoking cessation. QUALITY OF EVIDENCE MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched for randomized controlled trials, meta-analyses, and systematic reviews (level I evidence) pertinent to pharmacologic and nonpharmacologic smoking cessation therapie...

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