Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surfa...

Pharmaceutical contamination of shallow groundwater is a substantial concern in effluent-dominated streams, due to high aqueous mobility, designed bioactivity, and effluent-driven hydraulic gradients. In October and December 2012, effluent contributed approximately 99% and 71%, respectively, to downstream flow in Fourmile Creek, Iowa, USA. Strong hydrologic connectivity was observed between sur...

Size exclusion chromatography (SEC) is well established for mAb aggregate analysis. As the technique has been used since the early days of mAb development for pharmaceutical purposes, various method improvements have evolved. For instance, the benefits of arginine on analytical SEC of mAb aggregate samples are well-known. Herein, we present how SEC of mAb aggregate samples may take advantage of...

Proper chemical imaging tools are critical to the pharmaceutical industry due to growing regulatory demand for intermediate and end-product content uniformity testing. Herein we demonstrate stimulated Raman scattering (SRS) imaging of active pharmaceutical ingredient (API) and four excipients within tablets. Tablets from six manufactures were imaged with a speed of 53 s per frame of 512 × 512 p...

The intrinsic photostability characteristics of pharmaceutical active substances and medicinal products should be evaluated to demonstrate that, as appropriate, light exposure does not result in unacceptable change. The photostability of Finasteride, Diclofenac and Naproxen was studied. The irradiation of the samples was performed according to the conditions suggested by the ICH Guidelines [1] ...

A novel high resolution ion mobility spectrometer (HRIMS) equipped with an electrospray ionization (ESI) source was used to analyze the active pharmaceutical ingredients (APIs) that comprise many of the top selling drugs for use in cleaning validation (CV) of pharmaceutical manufacturing equipment. The ESI-HRIMS system allowed rapid analysis of pharmaceutical samples that were difficult to dete...

This paper describes zeroand first-order derivative spectrophotometric methods for determination of estradiol valerate in pharmaceutical preparations. The solutions of the standard and pharmaceutical samples were prepared in methanol. Absorbances of estradiol valerate were measured at 280 nm for zero-order by measuring height of peak from zero, at 292 nm for first-order derivative spectrophotom...

This paper evaluates the suitability of some smectite-rich samples from northern Patagonia (Argentina) for pharmaceutical use. The clays must comply with some general features before considering their use in pharmacy, including high mineral and chemical purity and the absence of microbial pathogens. Specific characteristics such as sediment volume, swelling power and gel formation are also impo...

OBJECTIVE This article reviews and summarizes eight ethical guidelines of major professional organizations regarding the pharmaceutical industry's role in the psychiatric education of trainees. METHOD The author conducted a literature review of research and guidelines pertaining to the pharmaceutical industry's relationship to trainees, with special attention to ethical implications. RESULT...

Funding combination is the most important issue for the companies while they know the amount of required capital. Companies should be careful regarding the appliance of financial providing methods compatible with the investment strategy of company and profitability. This study seeks to examine the relationship between the capital structure and the profitability of pharmaceutical companies in Ir...