A 53-year-old male presented with complaints of abdominal pain and weight loss. On physical exam he was noted to have mucocutaneous pigmentation around his lips and oral mucosa. Radiologic and endoscopic investigations demonstrated an obstructing mass in the second portion of the duodenum along with additional smaller soft tissue masses throughout the bowel. Histology of biopsied specimens reve...

The gastric polyps are rare as compared to the colonic polyps. Multiple gastric polyps are seen in association with other polyposis syndromes like juvenile polyposis, Gardner's syndrome, the Peutz-Jeghers syndrome and the Cronkhite-Canada syndrome. Diffuse gastric polyposis is a rare entity and only few cases have been reported. The mode of treatment is surgery, either total or near total gastr...

Peutz-Jeghers syndrome (PJS) is characterized by scattered black pigmentations on fingers and lips and multiple polyps in the gastrointestinal tract. Patients with PJS often have severe complications secondary to multiple large polyps. Herein, we present a young woman complicated with a large polyp in her colon without any clinical symptoms. We also emphasized the necessity of early diagnosis a...

A 21-year-old male reporting melena over one week is presented. Laboratory testing revealed severe anemia (Hgb 7 g/dL). Hyperpigmentation spots were present in the patient’s bucal mucosa and lower lip that arose during infancy. Three years ago, these lesions had raised the clinical suspicion of Peutz-Jeghers syndrome (PJS) and the patient had undergone an upper gastrointestinal (GI) endoscopy a...

Peutz-Jeghers syndrome (PJS,MIM 175200) is a disease of autosomal dominant inheritance that is characterised by hamartomatous gastrointestinal polyps and mucocutaneous pigmentation. In addition to problems such as intussusception, PJS predisposes to cancers of several sites. The unusual combination of clinical features makes the identification of the defect underlying PJS particularly interesti...