BACKGROUND The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate of hypoxia-sensitive PET tracers is slow, comparable to the rate of diffusive equilibration in some tissue types, including mucinous and necrotic tissue. This means that tracer ...

It is almost exactly 10 years since the first report of a PET ligand that specifically bound to a pathological protein in the brain was published (Klunk et al., 2004). This tracer, 11 C-Pittsburgh compound B (PIB), detected fibrillar aggregated forms of amyloid-b, the major constituent of the Alzheimer's disease plaque and, according to many, the initiating event in Alzheimer's disease patho-ge...

PET imaging using the glucose analog 18F-FDG as a tracer is an excellent method to detect small focal sites of high metabolic activity, which are frequently indicative of tumors. However, it is very difficult to identify the anatomic location of these focal sites precisely with PET alone. The only anatomic markers in FDG-PET are organs, such as the heart, that are known to have high metabolic r...

PURPOSE The prostate-specific membrane antigen (PSMA) was shown to be overexpressed on the neovasculature of several malignancies. Here, the role of Ga-HBED-CC-PSMA PET/CT for the detection of PSMA expression in patients with metastasized differentiated thyroid cancer (DTC) was evaluated. METHODS Six patients with iodine-negative and F-FDG-positive metastasized DTC (mean TG, 1616 ng/mL) recei...

   Various radiometal complexes have been developed for tumor imaging, especially Ga-68 tracer. In the present study, the development of a radiogallium bis-thiosemicarbazone complex has been reported. [67Ga] acetylacetonate bis(thiosemicarbazone) complex ([67Ga] AATS) was prepared starting [67Ga]Gallium acetate and freshly prepared acetylacetonate bis (thiosemicarbazone) (AATS) in 30 min at 90°...