Artemether exhibits diverse pharmacological effects and has multiple applications. This study aimed to investigate its antiproliferative and apoptogenic effects on HaCaT cells and keratinocyte differentiation-inducing activity in vivo. WST-8 analysis demonstrated that Artemether can inhibit the proliferation of cultured HaCaT cells in a time- and dose-dependent manner. Annexin V/PI dual stainin...

The aim of this study was to investigate radioprotective effect of the polysaccharides from soybean meal (SMP) against X-ray radiation-induced damage in mouse spleen lymphocytes. MTT and comet assay were performed to evaluate SMP's ability to prevent cell death and DNA damage induced by radiation. The results show that, X-ray radiation (30 KV, 10 mA, 8 min (4 Gy)) can significantly increase cel...

Objective: The goal of this study is to find out how Fragaria Ananassa (strawberries) affects serotonin levels and mouse immobility duration during the different tests performed in mice evaluate antidepressant effects FragariaAnanassa. Methods: Antidepressant compared with Standard drugs by performing a Forced Swim Test Tail Suspension on albino mice. was administered two distinct groups animal...

The length of casein mRNA from the lactating mouse mammary gland, as assessed on Northern blots, is shorter after weaning, but is elongated following the removal of milk. In order to investigate this phenomenon, the molecular structures of beta- and gamma-casein mRNAs were analysed. The coding and non-coding regions of the two forms were the same length, but the long form of casein mRNA had a l...

OBJECTIVE Bone morphogenic protein 4 (BMP4) is an important mediator of endothelial dysfunction in cardio-metabolic diseases, whereas platelet-derived growth factors (PDGFs) are major angiogenic and proinflammatory mediator, although the functional link between these 2 factors is unknown. The present study investigated whether PDGF mediates BMP4-induced endothelial dysfunction in diabetes melli...

Many mammals show epidermal patterning, as seen in alternating mouse tail scales and the microtopography of human skin surface. However, mechanisms underlying development such patterning are poorly understood. Here, we that type XVII collagen (COL17), a niche for stem cells, is factor determining patterning. Col17-null mice exhibit slender scales, condition alleviated by COL17 overexpression. A...

The actin-binding protein vinculin is a major constituent of focal adhesion, but its role in neuronal development poorly understood. We found that deletion mouse neocortical neurons attenuated axon growth both vitro and vivo. Using functional mutants, we expression constitutively active significantly enhanced while the head-neck domain had an inhibitory effect. Interestingly, vinculin-talin int...