نتایج جستجو برای: peroxynitrite

تعداد نتایج: 3024  

Journal: :The Biochemical journal 1996
K Briviba I Roussyn V S Sharov H Sies

The effect of the selenium-containing compounds selenomethionine, selenocystine and ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] on the oxidation of dihydrorhodamine 123 caused by peroxynitrite and on the nitration of 4-hydroxyphenylacetate by peroxynitrite was studied in comparison with their sulphur analogues methionine, cystine and ebsulfur [2-phenyl-1,2-benzisothiazol-3(2H)-one]. The s...

Journal: :American journal of physiology. Cell physiology 2000
P Liu B Xu J Quilley P Y Wong

In the present study, we examined the effects of peroxynitrite on reperfusion injury using a rat model of hepatic ischemia-reperfusion (HI/R). The left and median lobes of the liver were subjected to 30 min of ischemia, followed by 4 h of reperfusion. Groups A and B rats were sham-operated controls that received vehicle or peroxynitrite; groups C and D rats were subjected to HI/R and received p...

2001
Nathalie Moulian Frédérique Truffault Yvette Morot Gaudry-Talarmain Alain Serraf Sonia Berrih-Aknin

Most thymocytes are deleted by thymic selection. The mechanisms of cell death are far from being clear. Peroxynitrite is a powerful oxidant produced in vivo by the reaction of superoxide (O2) with nitric oxide (NO•) and is able to mediate apoptosis. The aim of this study was to analyze whether NO and peroxynitrite could play a role in human thymocyte apoptosis. The results indicate that 3-(4-mo...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998
D Saleh P Ernst S Lim P J Barnes A Giaid

Peroxynitrite is a potent oxidant formed by the rapid reaction of the free radicals nitric oxide (NO) and superoxide. It causes airway hyperresponsiveness and airway epithelial damage, enhances inflammatory cell recruitment, and inhibits pulmonary surfactant. Asthma is characterized by increased airway hyperresponsiveness, airway epithelial shedding, and inflammation. We examined the production...

Journal: :American Journal of Physiology-endocrinology and Metabolism 2021

Here we show that exogenous peroxynitrite results in nitration of phosphorylase as well inhibition glycogenolysis isolated intact mouse skeletal muscle during short-term repeated contractions. However, contractions the absence do not result or affect glycogenolysis, nor does addition antioxidants alter Thus is subject to redox control

Journal: :Environmental Health Perspectives 2003
Martin L Pall

The elevated nitric oxide/peroxynitrite and the neural sensitization theories of multiple chemical sensitivity (MCS) are extended here to propose a central mechanism for the exquisite sensitivity to organic solvents apparently induced by previous chemical exposure in MCS. This mechanism is centered on the activation of N-methyl-D-aspartate (NMDA) receptors by organic solvents producing elevated...

1998
CSABA SZABÓ LÁSZLÓ VIRÁG SALVATORE CUZZOCREA GWEN S. SCOTT PAUL HAKE MICHAEL P. O’CONNOR BASILIA ZINGARELLI ANDREW SALZMAN

Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADPribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS2/2) and corresponding wild-type animals (PARS1/1), with the aid of the lipophilic PARS inhibitor 5-iodo-6-am...

Journal: :The Journal of biological chemistry 1999
B Alvarez G Ferrer-Sueta B A Freeman R Radi

An initial rate approach was used to study the reaction of peroxynitrite with human serum albumin (HSA) through stopped-flow spectrophotometry. At pH 7.4 and 37 degreesC, the second order rate constant for peroxynitrite reaction with HSA was 9.7 +/- 1.1 x 10(3) M-1 s-1. The rate constants for sulfhydryl-blocked HSA and for the single sulfhydryl were 5.9 +/- 0.3 and 3.8 +/- 0.8 x 10(3) M-1 s-1, ...

Journal: :Archives of biochemistry and biophysics 2009
Homero Rubbo Andrés Trostchansky Valerie B O'Donnell

Lipid oxidation and nitration represents a novel area of research of relevance in the understanding of inflammatory processes. Peroxynitrite, the product of the diffusion-limited reaction between nitric oxide and superoxide anion, mediates oxidative modifications in lipid systems including cell membranes and lipoproteins. In this review, we discuss the mechanisms of lipid oxidation and nitratio...

Journal: :The Analyst 2012
Fabiao Yu Ping Song Peng Li Bingshuai Wang Keli Han

We present the design, synthesis, spectroscopy, and biological applications of PyBor, a new type of fluorescent probe for peroxynitrite detection in aqueous solution and living cells. The probe employs pyrene as the fluorophore, and is equipped with a chemically responsive unit boronate. The fluorescent probe can selectively detect peroxynitrite with fluorimetric determination and high-performa...

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