A review of the literature indicates that some compounds which produce hepatic peroxisome proliferation in rats also appear to produce Leydig cell adenomas, and some also affect the serum concentrations of testosterone and estradiol. Previous studies with the peroxisome proliferator ammonium perfluorooctanoate showed a direct effect on Leydig cells to alter steroidogenesis. It was therefore pro...

Early after stroke onset, ischemic injury is exacerbated by a robust inflammatory response that involves a local reaction as well as an influx of blood-borne cells recruited by cytokines, adhesion molecules, and chemokines. Among these cells, neutrophils are rapidly mobilized from the bone marrow to provide an effective innate immune response; they rapidly infiltrate into the ischemic brain (a ...

AimsTo evaluate the effects of fetal glucose infusion in late gestation on mRNA expression and protein abundance molecules involved regulation cardiac growth metabolism.Main methodsEither saline or was infused into sheep from 130 to 140 days (d) (term, 150 d). At d gestation, left ventricle tissue samples were collected. Quantitative real-time RT-PCR Western blot used determine key signalling w...