Objectives. The stratum corneum (SC) remains an obstacle to the passage of drugs applied topically. Severalinvestigations have focused on enhancing penetration through SC by integrating permeationenhancers (PE) into drug formulation. Terpenes are among PE utilized in formulations and categorized regulatory bodies as generally recognized safe (GRAS). This study aimed comparatively analyze skin p...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. it has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. to overcome the poor bioavailability of the drug, transdermal patches have been prepared. the present study also aims at optimization of ...