Low level laser therapy is defined to supply direct biostimulative light energy to the cells .It has been reported that low-level semiconductor diode lasers could enhance the wound healing process. The periodontal ligament is crucial for maintaining the tooth and surrounding tissues in periodontal wound healing. Low-level semiconductor diode lasers have been used in low-level laser therapy ,the...

Stromal cell-derived factor-1α (SDF-1α) is a key stem cell homing factor that is crucial for recruitment of stem cells to many diseased organs. However, the therapeutic activity of SDF-1α is potentially limited by N-terminal cleavage at position-2 proline by a cell surface protein CD26/dipeptidyl peptidase-IV (DPP-IV). Parathyroid hormone (PTH) is a DPP-IV inhibitor and has been suggested as a ...

In the last decades, term stem cells has been one of main topics to be discussed due its scientific and medical importance, since implementation in field medicine offers us very promising alternatives treatment above all solution diseases such as diabetes, Alzheimer, Parkinson's disease, cancer, treatments traumatology orthopedics, transplants, oral surgery, well reconstruction organs tissues i...

Tendon injuries are often associated with significant dysfunction and disability due to tendinous tissue's very limited self-repair capacity and propensity for scar formation. Dental-derived mesenchymal stem cells (MSCs) in combination with appropriate scaffold material present an alternative therapeutic option for tendon repair/regeneration that may be advantageous compared to other current tr...

Background: Surface roughness of dental implants impacts the survival adult periodontal stem cells and rate differentiation. This research was conducted to test how human ligament behaved on yttria stabilized tetragonal zirconia polycrystals polyetheretherketone (PEEK) discs with different surface topographies. Methods: Discs rough...

Periodontal ligament stem cells (PDLSCs) are promising cell resource for the cell-based therapy for periodontitis and regeneration of bio-root. In this study, we investigated the effect of PDLSCs on neutrophil, a critical constituent of innate immunity, and the underlying mechanisms. The effect of PDLSCs on the proliferation and apoptosis of resting neutrophils and IL-8 activated neutrophils wa...

BACKGROUND AND OBJECTIVE Orthodontic tooth movement requires remodeling of the periodontal tissues. The matrix metalloproteinases (MMPs) degrade the extracellular matrix components of the periodontal ligament, while the tissue inhibitors of metalloproteinases (TIMPs) control their activity. Synthetic MMP inhibitors have been developed to inhibit MMP activity. In this study, periodontal ligament...

Idiopathic root resorption is a very rare phenomenon. Resorption in tooth is brought about by odontoclastic activity. Special mechanisms in the periodontal ligament exist to prevent mineralization of the periodontal ligament and these periodontal ligament cells produce factors that inhibit mineralized tissue resorption and are capable of regulating bone and cementum formation. When this mechani...

Orthodontic force-induced stresses cause dynamic alterations within the extracellular matrix and within the cytoskeleton of cells in the periodontal ligament and alveolar bone, mediating bone remodelling, ultimately enabling orthodontic tooth movement. In the periodontal ligament and alveolar bone, the mechanically induced tensile strains upregulate the expression of osteogenic genes resulting ...