1. The reaction products of isoniazid with periodate-oxidized ribonucleosides and 5'-ribonucleotides have been characterized as the monohydrazones. 2. The stability, chromatographic and electrophoretic properties of the hydrazones are described. 3. (3)H-labelled isoniazid was shown to react with the 5'-linked terminal adenosine and cytidine groups of periodate-oxidized Escherichia coli transfer...

1951). These bodies usually occur with greatest frequency and staining intensity in smooth, virulent strains and diminish or disappear with colonial variation to rough, 0-inagglutinable forms. It was pointed out also that polar disposition of antigen would be more consistent with the observed pattern of end-to-end 0 agglutination (Pijper, J. Bact., 42, 345, 1941) than would an over-all surface ...

Under the conditions for oxidative degradation, with a 2-fold molar excess of periodate and cyclohexylamine at room temperature, *MP is degraded to inorganic phosphate but fails to release the base. In this latter respect, the parent pseudouridine behaves similarly. Under more drastic conditions, with a prolonged treatment at 4.5” and a 6-fold molar excess of periodate and cyclohexylamine, \kMP...

The A/Los Angeles/2/87 (H3N2) (A/LA/2/87) virus is sensitive to inhibitors of hemagglutination present in certain human sera. It was found that the effect of these inhibitors could be removed by treating sera with high-concentration receptor-destroying enzyme or trypsin-periodate or by using inhibitor-resistant viruses in the hemagglutination inhibition (HAI) test. Inhibitor-resistant viruses w...

Tetrahydro-1H-benzo[b]azonin-2,7-dione (2a) has been used as a precursor in the synthesis of dibenzo[b,f ][1,5]diazacyclododecene and dibenzo[b,g][1,6]diazacyclododecene ring systems 4 and 5, respectively, via periodate oxidation of the appropriate indolo-benzo[b]azonines 3 and 7. The synthesis of hexahydro-benzo[b][1,4]diazecin-2,7-dione (10) has been achieved by the Schmidt reaction of 2a. Th...

A new, simple, sensitive and selective method for the simultaneous determination of trace iron and aluminum by catalytic spectrophotometry was presented, based on the catalytic effects of iron and aluminum on the discoloring reaction of xylene cyanol FF proceeded by hydrogen peroxide and potassium periodate in weak nitric acid medium. No catalytic effect was obtained in the presence of hydrogen...

A simple and efficient method for selectively imaging and monitoring in situ the expression of sialylated glycoproteins on living cells has been developed. Treating living cells by mild periodate oxidation to selectively generate aldehydes on sialylated glycoproteins, followed by direct labeling of aldehydes with a commercially available fluorescent tag, fluorescein-5-thiosemicarbazide (FTSC), ...