BACKGROUND Perinatal asphyxia is associated with cardiac dysfunction. This may be secondary to myocardial ischaemia. Cardiac troponin T is the ideal marker for myocardial necrosis. Elevated levels in cord blood may be associated with intrauterine hypoxia and increased perinatal morbidity. AIMS To establish an upper limit of normal for cardiac troponin T concentration in the cord blood of infa...

OBJECTIVE We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants. STUDY DESIGN This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD. RESULTS Of 12,139 infants surviving to a ...

The Moro reflex is an infantile primitive that normally present in all infants and newborns. seen at birth it involuntary response to stimulation or abrupt body displacement. was first described by Austrian pediatrician Ernst 1918. It develops between the 28 32 weeks of gestation disappears 3-6 months age. Abnormalities highly specific for a variety perinatal injuries defects.

Cytomegalovirus (CMV) is the major cause of perinatal viral infections. One to two per cent of infants in the U. S. are congenitally infected; of these about 10% are or become symptomatic with such sequelae äs deafness and mental retardation. Such infants excrete CMV in the urine at birth. Another 5 per cent of infants are natally infected and begin to excrete virus at age 1-2 months. Natal inf...

OBJECTIVE The goal was to study whether postnatal magnesium sulfate infusion could improve neurologic outcomes at discharge for term neonates with severe perinatal asphyxia. METHODS Forty term (> or =37 weeks of gestation) neonates with severe perinatal asphyxia were studied in a prospective, longitudinal, placebo-controlled trial. Patients were assigned randomly to receive either 3 doses of ...

INTRODUCTION The Disability and Perinatal Care report published by the National Perinatal Epidemiology Unit and Oxford Regional Health Authority in 1994 emphasised that data on the neurodevelopmental outcomes of neonates requiring intensive care should be formally collected. Over the last 40 years, survival rates of high-risk infants have improved but these have not been matched with parallel i...

The risk of stroke is actually highest during the perinatal period. However, some newborn infants may have no signs indicative of the need of brain imaging, or brain images taken may not be sensitive enough to diagnose ischemic injuries; so, the diagnosis of stroke may be delayed several months or years. The neurological picture in patients with perinatal stroke detected through neuroimaging mo...

Background. The hygiene hypothesis suggests that high hygiene standards have led to an immune dysfunction and an increase in allergic diseases. Farming-related exposures are associated with a decreased risk of asthma. Since the gut microbiota may be a pivotal component in the hygiene hypothesis, we studied whether perinatal exposure to pets, doctor's diagnosed wheezy bronchitis (WB), and compos...

BACKGROUND In trials designed to estimate rates of perinatal mother to child transmission of HIV, HIV assays are scheduled at multiple points in time. Still, infection status for some infants at some time points may be unknown, particularly when interim analyses are conducted. METHODS Logistic regression models are commonly used to estimate covariate-adjusted transmission rates, but their met...

BACKGROUND Currently available clinical tools cannot accurately identify the extent of perinatal hypoxic injuries. During hypoxia, reactive oxygen species cause lipid peroxidation of cell membranes, yielding oxidation products that constitute thiobarbituric acid-reacting substances (TBARS). OBJECTIVE To see if the concentrations of TBARS excreted in urine would be elevated during the first da...