Finding the exact, quantum corrected metric on the hypermultiplet moduli space in Type II string compactifications on Calabi-Yau threefolds is an outstanding open problem. We address this issue by relating the quaternionic-Kähler metric on the hypermultiplet moduli space to the complex contact geometry on its twistor space. In this framework, Euclidean D-brane instantons are captured by contact...