In the 1970s, the identification of the histamine H2-receptor by Black and the subsequent development of histamine H2-receptor antagonists revolutionized our understanding and treatment of acid/peptic disorders. More recently, the identification of hydrogen-potassium-stimulated adenosine triphosphatase (H+/K(+)-ATPase) as the proton pump of the parietal cell and the recognition of the prominent...

background: although helicobacter pylori and non-steroidal anti-inflammatory drugs (nsaids) are the main causes of peptic ulcers disease (pud), recently the prevalence of idiopathic peptic ulcer (ipu) is increasing in most parts of the world. the aim of this study was to assess the prevalence of ipu in kerman, the center of largest province in south-east iran. methods : we included 215 patients...

INTRODUCTION Helicobacter pylori infection is a major cause of gastric ulcers, and Helicobacter pylori eradication drastically reduces ulcer recurrence. It has been reported, however, that severe physical stress is closely associated with gastric ulceration even in Helicobacter pylori -negative patients. CASE PRESENTATION We report the cases of a 47-year-old Japanese man and a 69-year-old Jap...

Laparoscopic fundoplication has become the standard surgical procedure for the treatment of gastroesophageal reflux diseases such as reflux esophagitis and hiatal hernia (1). Long-term complications of fundoplication include prolonged dysphagia, increased flatulence, gas-bloat syndrome, and gastric ulcers (GU). Of these complications, GU occurs in nearly 1-5% of the patients (2). These ulcers o...

BACKGROUND Perforated peptic ulcer is a serious complication of peptic ulcers with potential risk of grave complications. There is paucity of published reports on perforated peptic ulcer disease in our local environment. This study was conducted to evaluate the clinical presentation, management and outcome of patients with peptic ulcer perforation in our setting and to identify predictors of ou...

BACKGROUND We investigated the characteristic features and treatment of hemorrhagic peptic ulcers after the Great East Japan Earthquake, which occurred on 11 March 2011. METHODS Clinical data of patients with hemorrhagic peptic ulcers were retrospectively collected during the 3 months after the earthquake from seven major hospitals in the middle of the stricken area, and were compared with th...

Helicobacter pylori is a human pathogen that infects the stomach. More than half of the human population is infected with H. pylori, which is major cause of peptic ulcers, gastric cancers and mucosa-associated lymphoid tissue lymphoma. However, the majority of patients infected with H. pylori generally remain asymptomatic and never develop significant disease. H. pylori has high genetic diversi...

Abstract Aim We want to share our initial experience in treating Perforated Peptic ulcer by mini-invasive techniques. Method Retrospectively, data was collected looking at surgical files for patients who were admitted with perforated peptic Ulcers under an experienced consultant surgeon between 2016 and 2021 Benghazi Medical Centre Libya. Only managed laparoscopically included the same surgeon....