Seven different penicillins containing alpha-ketobutyric, beta-ketobutyric, gamma-ketovaleric, alpha-ketohexanoic, delta-ketohexanoic, epsilon-ketoheptanoic, and alpha-ketooctanoic acids as side chains have been synthesized in vitro by incubating the enzymes phenylacetyl coenzyme A (CoA) ligase from Pseudomonas putida and acyl-CoA:6-aminopenicillanic acid acyltransferase from Penicillium chryso...

Cell walls were prepared mechanically from both hyphae and conidia of Penicillium chrysogenum. The major carbohydrate components of cell wall hydrolysates were glucose, galactose and glucosamine, with lesser amounts of mannose and rhamnose. The conidia were richer in galactose and the hyphae contained more glucosamine. The distribution of the monomers in acidsoluble and alkali-soluble fractions...

T H E parasexual cycle first demonstrated in Aspergillus nidulans ( PONTECORVO, ROPER, HEMMONS, MACDONALD and BUFTON 1953) has provided a means for genetic investigations in other species of filamentous fungi, particularly those lacking a perfect stage. In the genus Penicillium, the parasexual cycle has been demonstrated in P. chrysogenum (PONTECORVO and SERMONTI 1954) , P. expansum ( BARRON 19...

Aspergillus nidulans and Penicillium chrysogenum produce specific cellular siderophores in addition to the well-known siderophores of the culture medium. Since this was found previously in Neurospora crassa, it is probably generally true for filamentous ascomycetes. The cellular siderophore of A. nidulans is ferricrocin; that of P. chrysogenum is ferrichrome. A. nidulans also contains triacetyl...

Hepatitis C virus (HCV) NS3-NS4A protease is an attractive target for anti-HCV agents because of its important role in replication. In this work, we demonstrated that the ethyl acetate extract of the endophytic fungus Penicillium chrysogenum exhibited a potent activity against HCV NS3-NS4A protease with an IC50 value of 20 microg/ml. The fungus was isolated from the red alga Liagora viscida and...

fungi associated with ascocarps of terfezia claveryi, tirmania nivea, t. pinoyi, picoa lefebvrei and p. juniperi in iran showed a wide range of genera and species in 94 samples collected during 2005–2009 from different regions including fars, systan and baluchestan, kerman, east azarbaijan, khuzestan, kermanshah and hormozgan provinces. thirty two species belonging to 21 genera were recovered f...

BACKGROUND Penicillium chrysogenum, the main production strain for penicillin-G, has a high content of intracellular carbohydrates, especially reduced sugars such as mannitol, arabitol, erythritol, as well as trehalose and glycogen. In previous steady state C wash-in experiments a delay of labeling enrichments in glycolytic intermediates was observed, which suggests turnover of storage carbohyd...