OBJECTIVE To describe the case-fatality rate (CFR) and risk factors of death in children with community-acquired acute pneumonia (CAP) in a pediatric university hospital. METHOD A longitudinal study was developed with prospective data collected from 1996 to 2011. Patients aged 1 month to 12 years were included in the study. Those who left the hospital against medical orders and those transfer...

In the majority of cases of bacterial endocarditis the causal organism is sensitive to benzylpenicillin (Finland and Barnes, I970). Thus this antibiotic is widely used in the treatment of endocarditis and its curative value and low toxicity are well proved. It is common for benzylpenicillin to be given in large doses by the intravenous route for a period of weeks to ensure eradication of the in...

Australian and New Zealand Journal of Public Health 1 © 2015 Public Health Association of Australia Benzathine benzylpenicillin G (BPG) is a beta-lactamase antibiotic developed in 1951.1 Administered intramuscularly, BPG has low in vivo solubility, producing prolonged serum penicillin concentrations. This makes BPG suitable for treating penicillin-sensitive organisms responsive to extended, low...

BACKGROUND Benzathine penicillin G every 3 weeks is the standard protocol for secondary prophylaxis for recurrent rheumatic fever. OBJECTIVE Assess the effect of Benzathine penicillin G on Streptococcus sanguinis and Streptococcus oralis in patients with cardiac valvular disease due to rheumatic fever receiving secondary prophylaxis. METHODS Oral streptococci were evaluated before (baseline...

We introduce a new smooth, non-toxic, biocompatible method for cross-linking of gum tragacanth (GT), a polysaccharide of natural origin, in order to serve as a new supporting matrix for immobilization systems. The modified gum is used as a matrix for the catalysis of the conversion of benzyl penicillin to 6-aminopenicillanic acid (6-APA) by means of Escherichia coli ATCC11105 with penicillin G ...

The inhibition performances of nafcillin (III), methicillin (II) and penicillin G (I) on the corrosion of copper in HCl was studied and tested by weight loss, Tafel polarization, SEM, UV-vis spectrophotometry, molecular dynamics method and quantum chemical calculations. Polarization curves indicated that the studied inhibitors act as mixed-type inhibitors. The values of inhibition efficiency an...

Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. In this review, the latest achievements in the production of recombinant enzymes are discussed, as well as the results of PA type G protein engineering.

Individual approaches to the diagnosis and management of penicillin allergy are practiced by clinicians. This cross-sectional survey of physicians was aimed at exploring their ways of dealing with diagnosis and management of penicillin G allergy. Of the 235 respondents, 63% believed patients’ self-reported history of penicillin allergy and avoided using penicillin G; 97% do so for patients whos...

D-Alanine carboxypeptidase from Bacillus stearothermophilus is a membrane-bound enzyme which is inhibited by covalent interaction with penicillin G. The penicilloyl enzyme spontaneously reactivates and simultaneously releases a penicillin G degradation product; 0.2 mumol of the latter was isolated after incubation of 4.2 mumol of [8-14C]penicillin G with 10 g of membrane protein. It was identif...