Genotype 5 hepatitis C has been poorly studied despite its worldwide spread. We have analyzed the early kinetics of genotype 5 hepatitis C virus RNA during pegylated interferon/ribavirin treatment in a 59-year-old man with active liver necroinflammatory changes and advanced liver fibrosis. The patient had a high viral load but a small serum level of hepatitis C core antigen. On combination anti...

The development of new direct acting antiviral drugs for the treatment Hepatitis C virus infection, has made it possible to obtain an excellent cure rate and extend indications eradication previously very difficult populations treat like cystic fibrosis, in whom with classic regimens based on pegylated Interferon plus ribavirin could favor worsening lung function. We present a case 41-year-old ...

We report a rare case of severe autoimmune hemolytic anemia triggered by pegylated interferon during combination therapy for chronic HCV. This case demonstrated that interferon can de novo induce autoimmune hemolytic anemia during therapy for chronic hepatitis C in a previously healthy patient.

H C virus (HCV) infects 170 million people worldwide (1). The infection becomes chronic in 85%–90% of cases with potential to cause cirrhosis, end-stage liver disease, and hepatocellular carcinoma (HCC) (2). Treatment of HCV infection has evolved significantly over the last 20 years since the introduction of interferon-α in 1991. Initial studies using interferon were disappointing with response...

Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthy...

BACKGROUND : Interferon-gamma (INF-γ) is an important cytokine in the immune response against Mycobacterium tuberculosis. activates macrophage to kill intracellular mycobacterium. AIM: The aim of this study determine difference plasma INF-γ level pulmonary tuberculosis (PTB) patients compared a healthy control and factors associated with interferon-gamma level. METHODS: This case–control study....

OBJECTIVES The effects of antiretroviral drugs on the response to pegylated interferon plus ribavirin remain uncertain. We evaluated whether antiretroviral drugs affected the response to pegylated interferon plus ribavirin in patients co-infected with HIV and hepatitis C virus (HCV). METHODS We conducted a retrospective analysis of two cohorts of HIV/HCV-co-infected patients treated with pegy...

Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical modification. We show that native disulfides in human interferon alpha-2b and in a fragment of an antibody to CD4(+) can be modified by site-specific bisalkylation of the two cysteine sulfur atoms to form a three-carbon PEGylated bridge. ...

introduction patients with hepatitis c are commonly treated with combination of pegylated interferon alfa-2a and ribavirin. less than 1% of patients receiving this treatment experience very uncommon ophthalmological side effects such as optic neuropathy and vision disorder, which are usually subclinical, mild and reversible, not requiring the withdrawal of the treatment. retinopathy is the most...

We report a case of new interferon-associated ocular complication during treatment with combination of pegylated interferon plus ribavirin for chronic hepatitis C infection. Our patient developed choroidal neovascularization in addition to the classic interferon associated retinopathy. Choroidal neovascularization has not been reported before in association with interferon induced retinopathy. ...