Jab1 (Jun activation domain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability of many tumor suppressors and cell cycle regulators and is therefore a novel target in cancer therapy. Curcumin, an inhibitor of Jab1/CSN-associated kinase(s), has been reported to suppress tumor growth; however, curcumin is highly hydrophobic, and this feature prevents it...

The influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated {PEG [poly(ethylene glycol)]-conjugated} haemoglobin has been investigated. The sites and the extent of PEGylation of haemoglobin by reductive alkylation are not influenced by the presence of an alphaalpha-fumaryl cross-link at Lys-99(alpha). The propylated hexaPEGylated cross-linked ...

Abstract Background In an attempt to prove biological activity enhancement upon escalating the cellular uptake response through ligand and carrier-based via nanoframework, gallic acid was chosen be formulated into PLGA-based polymeric nanoparticles with iron oxide as theranostic agent. Results The pre-formulation studies like FTIR, DSC, XRD, TGA were carried out, which implies good compatibilit...

Fluorescently-labelled nanoparticles show great promise for nanoparticle tracking and detection in biological or medical applications. However, these fluorescent molecules functionalized on the surface of can impact interaction with biomolecules, cells, subsequently influence their uptake. To explore extent interactions, PEGylated gold were six structurally different dyes to demonstrate that pr...

Objective: The purpose behind this study was to determine the frequency of erectile dysfunction in patients receiving pegylated interferon and ribavirin for treatment chronic hepatitis C.
 Study Design: Prospective observational study.
 Setting: Department Gastroenterology Hepatology, Medical Unit III, Services Hospital, Lahore.
 Period: Six months from 10st July 2017 9th January...

Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical modification. We show that native disulfides in human interferon alpha-2b and in a fragment of an antibody to CD4(+) can be modified by site-specific bisalkylation of the two cysteine sulfur atoms to form a three-carbon PEGylated bridge. ...

hepatitis c virus (hcv) has chronically infected million peoples worldwide. spontaneous viral clearance occurs in 25% of affected patients.  the standard regimen to treat hcv infection is the combination of pegylated interferon and ribavirin.

This study examines the potential of poly(lactic-co-glycolic acid) (PLGA) nanoparticles functionalized with poly(zwitterion)-mannose brushes to target macrophages. Uptake studies RAW 264.7 macrophages indicate that multiple mannose-binding sites in grafted facilitate interaction mannose receptor macrophages, resulting approximately four times higher cellular uptake than monolayer coatings. To t...

Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded i...