Introduction : Nowadays, using drug delivery is an essential method to improve cancer therapy through decreasing drug toxicity and increasing efficiency of treatment. Silibinin (C25H22O10), a polyphenolic flavonoid which is isolated from the milk thistle plant, has various applications in cancer therapy but it has hydrophobic structure with low water solubility and bioavailability. To increase ...

in-vitro labeling of rbc with 99mtc is an intricate procedure and there is always a need foran alternate blood pool imaging agent. the aim of this study was to prepare an effective nanosized liposome (nls) similar to human rbc for blood pool scintigraphy. this study formulatespeg-nls and non-peg-nls using film method plus high pressure homogenization technique.biodistribution studies were perfo...

A novel micropattern-assisted nanoassembly (μPAN) method to organize highly ordered nanocolloidal arrays onto a nonfouling polymeric surface is reported. A high-density array of polyethylene glycol (PEG) hydrogel microwells is first fabricated on glass substrates with the minimal feature resolution of 1 μm using photolithography method. By simply controlling the colloidal concentration of the d...

Percutaneous endoscopic gastrostomy (PEG) has gradually gained the popularity since its invention and become the most preferred method for gastrostomy insertion in recent years. PEG is associated with lower morbidity and mortality and has the advantages of being minimally invasive and more convenient over the conventional open gastrostomy. However, significant rates of major complication still ...

In general, atherosclerosis is considered to be a form of chronic inflammation. Dexamethasone has anti-inflammatory effects in atherosclerosis, but it was not considered for long-term administration on account of a poor pharmacokinetic profile and adverse side effects. Nanoparticles in which drugs can be dissolved, encapsulated, entrapped or chemically attached to the particle surface have abil...

Surfaces covered with polyethylene glycol (PEG; HO-(CH(2)-CH(2)-O)(n)-H) have been shown to be biocompatible because PEG's properties yield nonimmunogenicity, nonantigenicity, and protein rejection. To produce a biocompatible surface coating, we have developed a method for grafting PEG onto activated silica films. We first deposited an amorphous silica film by plasma-enhanced chemical vapor dep...

An 80-year-old woman with a nasogastric tube in situ for cerebral infarction sequelae was referred for percutaneous endoscopic gastrostomy (PEG). The abdominal computed tomography scan on admission showed that the transverse colon was interposed between the anterior abdominal wall and the stomach (●" Fig.1). The usual PEG placement posed a high riskof piercing the transverse colon. A fluoroscop...

Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions. PEGylation has become a sophisticated method to decrease that immunogenicity. In this report, according predicted epitope from the active center, five residues, including Gly79, Leu82, Lys84, Ala97, and Arg104 have bee...

Feedstock for powder injection moulding of silver was prepared using water-soluble binder composed polyethylene glycol (PEG) and polyvinyl butyrol (PVB). Silver powders with particle size in range 1 μm to 20 can be mixed PEG/PVB system form feedstocks having loadings 42 vol% 45 vol%. PEG removed water leaching method while PVB by thermal debinding. Specimens retained their shapes during debindi...

due to unique applications of palladium nanoparticles, synthesis of these nanoparticles by a simple andlow cost method is very important. in this work, pd nanoparticles were synthesized with narrow sizedistribution by loading metal salt (pd(oac)2 ) into the polymeric matrix (peg) as reducing agent andstabilizer. also, the effect of metal salt concentration and peg molecular weight on the conver...