Current anticancer chemotherapy often suffers from poor tumor selectivity and serious drug resistance. Proper vectors for targeted delivery and controlled drug release play crucial roles in improving the therapeutic selectivity to tumor areas and also overcoming the resistance of cancer cells. In this work, we developed a novel human serum albumin (HSA) protein-based nanocarrier system, which c...

While a host of methods exist to deliver genetic materials or small molecules to cells, very few are available for protein delivery to the cytosol. We describe a modular, light-activated nanocarrier that transports proteins into cells by receptor-mediated endocytosis and delivers the cargo to the cytosol by light triggered endosomal escape. The platform is based on hollow gold nanoshells (HGN) ...

The blood-brain barrier acts as a physical barrier that prevents free entry of blood-derived substances, including those intended for therapeutic applications. The development of molecular Trojan horses is a promising drug targeting technology that allows for non-invasive delivery of therapeutics into the brain. This concept relies on the application of natural or genetically engineered protein...

Systemic administration of chemotherapy for cancer often faces drug resistance, limiting its applications in cancer therapy. In this study, we developed a simple multifunctional nanocarrier based on polyethylenimine (PEI) to codeliver doxorubicin (DOX) and BCL2 small interfering RNA (siRNA) for overcoming multidrug resistance (MDR) and enhancing apoptosis in MCF-7/Adr cancer cells by combining ...

To ensure targeting of apoferritin nanocarrier with encapsulated doxorubicin drug, we used a peptide linker based on a protein G with N-terminus affinity towards Fc region of antibodies. To connect the peptide to the surface of apoferritin, the C-terminus of peptide was made of cysteine with affinity to gold. The surface of apoferritin with encapsulated doxorubicin (APODOX) was coated either wi...

Taste is the most crucial organoleptic parameter affecting patient compliance in case of drugs with poor palatability. masking a major challenge for development orally ingested active pharmaceutical constituents industry. Numerous conventional taste-masking techniques have been extensively studied. In parallel, drug solubility or release concern techniques. Recently, many nanocarrier systems in...

OBJECTIVE To evaluate the cytotoxicity of poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-PDLLA) nanovesicles loaded with doxorubicin (DOX) and the photosensitizer hematoporphyrin monomethyl ether (HMME) on human hepatocellular carcinoma HepG2 cells and to investigate potential apoptotic mechanisms. METHODS PEG-PDLLA nanovesicles were simultaneously loaded with DOX and HMME (PEG-PDLLA-...

the objective of the present study was to investigate the role of nanocarrier of magnetic isotope of 25-mg2+ (pmc16) in liver toxicity, atp content and oxidative stress due to malathion (mal) exposure. pmc16 nanoparticle were administered in different doses (0.05, 0.1 and 0.2 ld50) intravenously (iv) 40 minutes after a single mal (0.25 ld50= 207 mg/kg) intraperitoneal (ip) injection as a comple...

We developed a novel active nanocarrier of common antibiotics, which can efficiently degrade biofilms resistant bacteria and bypass their defences.