Aim: 1) To increase water solubility of indomethacin drug using mixed solvency approach. 2) To employ use of non toxic solubilizers for increasing solubility of a poorly water soluble drug. Study Design: Trial and error based experimental study. Place and Duration of Study: School of Pharmacy, Devi Ahilya Vishwavidyalaya, UTD, Takshashila Campus, Indore, India and College of Pharmacy, IPS Acade...

Abstract The use of zinc oxide (ZnO) and titanium (TiO 2 ) nanoparticles in ultraviolet (UV) filters can cause serious health issues due to their genotoxicity cytotoxicity effect. Recent research on cerium (CeO has demonstrated biocompatible nature, excellent antioxidant ultraviolet–visible (UV–Vis) absorption properties. CeO -based nanocomposite materials or nano-architectures offer uniform ab...

AIM The objective of this study was to estimate the average cost of diagnosis and treatment of hepatitis C among patients based on their treatment regime, during the one course of treatment and six-month after stopping that. BACKGROUND Hepatitis C virus (HCV) infection is a major cause of liver-related morbidity and mortality worldwide and a major public health problem. PATIENTS AND METHODS...

purpose: to compare the complications of pegging between the polycarbonate peg system and the titanium peg system. method: complications associated with pegging (polycarbonate: bio-eye or titanium: dr-perry new p-k) were reviewed from the hospital records of 153 patients over 5 years. results: out of 153 cases, 96 (62.3%) were male and 57 (37.7%) were female. mean age was 27.7 yr (6-59 yr). in ...

In this work, casting method was used to fabricate the polyvinyl alcohol (PVA)/ poly ethylene glycol (PEG) nanocomposite with different content of titanium nitrate nanoparticle (TiN NPs). This analyzed use a Spectrophotometry spectral region 200-800 nm. The absorption enhances when added TiN NPs polymeric matrix which may be for various applications such as optoelectronic detector. optical ener...

This work describes the development and testing of poly(ethylene glycol) (PEG) hydrogels with independently controlled dimensions of wide and deep macrochannels for their ability to promote alignment of skeletal myoblasts and myoblast differentiation. A UV-photopatterned thiol-ene mold was employed to produce long channels, which ranged from ∼40 to 200 μm in width and from ∼100 to 200 μm in dep...

Adiponectin plays multiple critical roles in modulating various physiological processes by binding to its receptors. The functions of PEG-BHD1028, a potent novel peptide agonist AdipoRs, was evaluated using vitro and vivo models based on the reported action spectrum adiponectin. To confirm design concept sites their affinities were analyzed SPR (Surface Plasmon Resonance) assay. results reveale...

Nanotechnology is a promising approach both for restoring or enhancing activity of old and conventional antimicrobial agents and for treating intracellular infections by providing intracellular targeting and sustained release of drug inside infected cells. The present paper introduces a formulation study of gentamicin loaded biodegradable nanoparticles (Nps). Solid-oil-in water technique was st...

Novel pH-responsive complexation hydrogels containing pendent glucose (P(MAA-co-MEG)) or grafted PEG chains (P(MAA-g-EG)) were synthesized by photopolymerization. The feasibility of these hydrogels as oral protein delivery carriers was evaluated. The pH-responsive release behavior of insulin was analyzed from both P(MAA-co-MEG) and P(MAA-g-EG) hydrogels. In acidic media (pH 2.2), insulin releas...