A linkage analysis for finding inheritance states and haplotype configurations is an essential process for linkage and association mapping. The linkage analysis is routinely based upon observed pedigree information and marker genotypes for individuals in the pedigree. It is not feasible for exact methods to use all such information for a large complex pedigree especially when there are many mis...

Abstract Quantifying fitness is important to understand adaptive evolution. Reproductive values are useful for making comparisons involving different categories of individuals, like males and females. By definition, the reproductive value a category expected per capita contribution members that gene pool future generations. Life history theory reveals how can be determined via estimation life-h...

Increased concern for the welfare of pedigree dogs has led to development of selection programs against inherited diseases. An example is canine hip dysplasia (CHD), which has a moderate heritability and a high prevalence in some large-sized breeds. To date, selection using phenotypes has led to only modest improvement, and alternative strategies such as genomic selection (GS) may prove more ef...

Linkage analysis using allele-sharing methods is a trait-model free approach to test for the location of a disease gene by studying the joint inheritance pattern of genes at different loci. For large pedigrees, the space of inheritance vectors becomes large and unavailability of data on individuals makes the probability computation of multilocus inheritance pattern almost infeasible. MCMC techn...

A pedigree is a directed graph that displays the relationship between individuals according to their parentage. We derive a combinatorial result that shows how any pedigree-up to individuals who have no extant (present-day) ancestors-can be reconstructed from (sex-labelled) pedigrees that describe the ancestry of single extant individuals and pairs of extant individuals. Furthermore, this recon...

The relationship between pairs of individuals is an important topic in many areas of population and quantitative genetics. It is usually measured as the proportion of the genome identical by descent shared by the pair and it can be inferred from pedigree information. But there is a variance in actual relationships as a consequence of mendelian sampling, whose general formula has not been develo...

PURPOSE To characterize the clinical features of a Chinese pedigree with Blau syndrome and to identify mutations in the NOD2/CARD15 (nucleotide-binding oligomerization domain containing 2/caspase recruitment domain family, member 15) gene. METHODS Clinical features of this family were evaluated. Genomic DNA was obtained from blood samples, and all exons of NOD2/CARD15 were amplified by polyme...

The spirit of Party-building is the root Communist’s spiritual pedigree. Chinese Communists have always attached importance to condensed and inherited Party-building. great founding Party Red Boat are also expressions spirit, so it significance clarify relationship between two, discover their positioning, give play respective values continue move towards new goal. which underpins higher politic...

UNLABELLED Computing the probability of identity by descent sharing among n genes given only the pedigree of those genes is a computationally challenging problem, if n or the pedigree size is large. Here, I present a novel graphical algorithm for efficiently computing all generalized kinship coefficients for n genes. The graphical description transforms the problem from doing many recursion on ...