Correspondence to Gary S Gilkeson; [email protected] In the last six months, Lupus Science and Medicine has published two papers by Robinson et al 2 that were secondary analyses and substudies of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) study. The major emphasis of the two papers was (1) the association of vitamin D levels at baseline with inflammatory markers, et...

Childhood vasculitis is a challenging and complex group of conditions that are multisystem in nature and often require integrated care from multiple subspecialties including rheumatology, dermatology, cardiology, nephrology, neurology, and gastroenterology. vasculitis is defined as the presence of inflammation in a blood vessel that may occur as a primary process or secondary to an underlying d...

Introduction. Neonatal lupus erythematosus (NLE) is an acquired disease of the newborn caused by transplacental transfer of maternal anti-Ro/SSA, anti-La/SSB, and infrequently anti-U1 RNP antibodies. Methodology. This is a case report of a male infant delivered via Caesarean section at 36-week gestation following detection of fetal bradycardia during routine antenatal clinic visit. Results. The...

SUMMARY During the course of systemic lupus erythematosus in a 10 year-old girl, a go it er develo ped. Subc linical I ly pothyrnic.Jism was found, in addition rising titer of ant imicrosomal antibody and overt hypothyroidism after 6-week cessation of thyroxin tablet lead to the diagnosis of Hashimoto's thyroiditis. Antibodies directed to the thyroid may result in an autoimmune thyroiditis in...

Pediatric SLE (pSLE) is a chronic multisystem autoimmune disease with remitting, relapsing course and onset of symptoms before age 18 years, accounting for approximately 20% of all SLE. This clinically heterogeneous disease is characterized by a distinct spectrum of autoantibodies including antinuclear antibody (ANA), double-stranded deoxyribonucleic acid (dsDNA), and antibodies against extract...

BACKGROUND Arthritis is one of the most common manifestations of systemic lupus erythematosus (SLE). Although typically non-erosive and non-deforming, children with SLE arthritis can have significant morbidity with decreased quality of life. Our goal was to identify potential clinical and laboratory predictors of arthritis in a cohort of pediatric patients with SLE. METHODS We performed a coh...