The European Pediatric Pharmaceutical Legislation wants children to benefit more from pharmaceutical progress. In rare diseases, concerns have been raised that this legislation might damage research and stymie drug development. We discuss the role of the European Medicines Agency (EMA) and its Pediatric Committee (PDCO) in the development of ivacaftor, first-in-class for cystic fibrosis (CF) pa...

Accessible online at: www.onkder.org 1Department of Pediatric Hematology and Oncology, İstanbul University Cerrahpaşa Faculty of Medicine and Institute of Oncology, İstanbul-Turkey 2Department of Pediatric Gastroenterology, Selcuk University Faculty of Medicine, Konya-Turkey 3Department of Pediatric Infectious Diseases, Selcuk University Faculty of Medicine, Konya-Turkey 4Department of Ophthalm...

Background: The growing prevalence of chronic diseases in children has increased their need for palliative care. We aimed to compare pediatric palliative care and home care training in Iran and in the selected countries. Materials and Methods: This comparative study was conducted based on the classifications of palliative care for children and using databases such as Scopus, Science Direct, Ovi...

BACKGROUND Previous studies comparing children with cardiac disease with children with lung disease or healthy children indicated that natriuretic peptides are promising markers in pediatric patients. The aim of this study was to further clarify the diagnostic usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements in a less preselected population of children younger th...

Comparative-effectiveness research (CER) is a hot topic. There are several definitions for CER, but the Institute ofMedicine defines CER as “the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat andmonitor a clinical condition or to improve the delivery of care” [1]. Comparative-effectiveness research focuses more on eff...

ABSTRACT Pediatric early warning system (PEWS) can be an detection of worsening in pediatric patients with chronic diseases, quantitative studies related to the implementation PEWS children diseases have been carried out various countries including USA, Guatemala and China. The purpose this review is determine diseases. This literature study uses a method approach, data sources through Proquest...

echocardiography is considered the primary diagnostic tool for congenital heart diseases. the pediatric echocardiography diagnostic errors, consisting of false positive or discrepant diagnoses, picked up within a 2.5-year period in our pediatric echocardiography laboratory are presented herein. in this case report, the factors contributing to the diagnostic errors are categorized as cognitive s...

During the past 2 years, worldwide considerable advances have been made in the field of pediatric cardiology, including the elucidation of the mechanisms responsible for cardiovascular diseases and the development of diagnostic techniques and treatment strategies. Meanwhile, we should be aware that the genetics, environmental factors and their interactions involved in the mechanisms for a varie...

Conditions Has Higher Case Fatality and Unique Serotype Distribution Inci Yildirim, MD, MSc; Kimberly M. Shea, PhD, MPH; Brent A. Little, PhD; Amy Silverio, BS; Katherine Hsu, MD, MPH; Stephen I. Pelton, MD; Pediatric Infectious Diseases, Boston Medical Center, Boston, MA; Epidemiology, Boston University School of Public Health, Boston, MA; Boston Medical Center, Boston, MA; Division of STD Pre...