Novel 3-C-alkylated-Neu5Ac2en derivatives have been designed to target the expanded active site cavity of influenza virus sialidases with an open 150-loop, currently seen in X-ray crystal structures of influenza A virus group-1 (N1, N4, N5, N8), but not group-2 (N2, N9), sialidases. The compounds show selectivity for inhibition of H5N1 and pdm09 H1N1 sialidases over an N2 sialidase, providing e...

This paper explains the development of a three-wheeled electric cart that not only is a means of transportation, but also provides the driver with a way of getting some physical exercise. Based on an investigation of the physiological decline accompanying aging, pedaling was chosen to implement the function of maintaining or improving physical strength; and an ergonomically designed pedal unit ...

The aim of our study was to compare crank torque profile and perceived exertion between the Monark ergometer (818 E) and two outdoor cycling conditions: level ground and uphill road cycling. Seven male cyclists performed seven tests in seated position at different pedaling cadences: (a) in the laboratory at 60, 80, and 100 rpm; (b) on level terrain at 80 and 100 rpm; and (c) on uphill terrain (...

objective(s):the present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (uco) on the dorsal hippocampal neurons in rats. materials and methods:sixty four male sprague-dawley rats aged 4 months were divided into two groups of sham and uco. these two groups were further divided into 4 sets of histopath...

purpose: to compare repeated intravitreal injections of bevacizumab (ivb) with triamcinolone acetonide (ivt) for treatment of acute branch retinal vein occlusion (brvo). methods: this randomized clinical trial included, 86 eyes with recent onset (less than 12 weeks) brvo. participants were randomly assigned to two treatment groups: the ivb group (43 eyes) consisted of patients who received mont...

Pedaling exercise on a bicycle ergometer is possible for spinal cord injured (SCI) and stroke patients who are preparing to maintain or recover functional movement abilities. The aims of this study are to develop tailor-made stimulation paradigms that can be applied to varied groups of subjects including complete and incomplete SCI, and stroke subjects for FES-cycling training. Compared to para...