AIMS Stimulated release of tissue-type plasminogen activator (t-PA) is pivotal for an intravascular fibrinolytic response and protects the circulation from occluding thrombosis. Hence, an impaired t-PA production is associated with increased risk for atherothrombotic events. A pharmacological means to stimulate the production of this enzyme may thus be desirable. We investigated if the anti-epi...

Previous studies have suggested that water-soluble polysaccharides from fermented carrot pulp (WSP-p) stronger anti-diabetic effects than those un-fermented (WSP-n). This study aimed to improve understanding of these functional differences by comparing their molecular structures. Weight-average weights WSP-p fractions were lower the corresponding WSP-n fractions. While both WSPs had similar gro...

Phosphatidic acid and lysophosphatidic acid are minor but important anionic bioactive lipids involved in a number of key cellular processes, yet these molecules have a simple phosphate headgroup. To find out what is so special about these lipids, we determined the ionization behavior of phosphatidic acid (PA) and lysophosphatidic acid (LPA) in extended (flat) mixed lipid bilayers using magic an...

Glycyrrhiza glabra residue (GGR) was efficiently subjected to concentrated phosphoric acid (PA) pretreatment with/without surfactant assistance, and promising results were obtained following separate enzymatic hydrolysis and fermentation (SHF) of the biomass. Pretreatment was carried out using 85 % PA either at 50 or 85 °C with 12.5 % solid loading for 30 min. In parallel experiments, ...

The aim of this study was to determine the effects high CO2 with constant O2 level on postharvest quality fig cv. Bursa Siyahi. For purpose, atmospheric compositions 3% + 10% (PA-1), 15% (PA-2), 20% (PA-3), and 21% 0.03% (RA) were tested under a palliflex controlled atmosphere (PA) storage system at 0°C for 28 days. At end storage, weight loss increased during period, but increase slowed down i...

Greater amounts of physical activity (PA) and omega-3 fatty acids have both been independently associated with better cognitive performance. Because of the overlapping biological effects of omega-3 fatty acids and PA, fatty acid intake may modify the effects of PA on neurocognitive function. The present study tested this hypothesis by examining whether the ratio of serum omega-6 to omega-3 fatt...

Pickering emulsions stabilized by the interaction of palmitic acid (PA) and silica nanoparticles (SiNPs) at water/oil interface have been studied using different alkane oil phases. The SiNPs has a strong synergistic character in relation to emulsion stabilization, leading an enhanced stability that only fatty acid. This results from formation acid-nanoparticle complexes driven hydrogen bond int...

We employed a multivalent peptide-library screening technique to identify a peptide motif that binds to phosphatidic acid (PA), but not to other phospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS). A tetravalent peptide with the sequence motif of MARWHRHHH, designated as PAB-TP (phosphatidic acid-binding tetravalent peptide), was shown to b...

The potential contribution of serine/threonine-specific protein phosphatases in the transcriptional regulation of plasminogen activator and plasminogen activator inhibitor gene expression was explored in human HT-1080 fibrosarcoma and U-937 monocyte-like cells using okadaic acid, a potent and specific inhibitor of phosphatases 1 and 2A (PP1 and PP2A). In both cell types okadaic acid induced pla...

The structure of dietary triacylglycerols is thought to influence fatty acid and calcium absorption, as well as intestinal microbiota population of the host. In the present study, we investigated the impact of palmitic acid (PA) esterified at the sn-2 position on absorption of fatty acid and calcium and composition of intestinal microorganisms in rats fed high-fat diets containing either low sn...