نتایج جستجو برای: pdgfr β

تعداد نتایج: 178428  

2018
Michael Ehrhardt Rogerio B Craveiro Julia Velz Martin Olschewski Anna Casati Stefan Schönberger Torsten Pietsch Dagmar Dilloo

Aberrant receptor kinase signalling and tumour neovascularization are hallmarks of medulloblastoma development and are both considered valuable therapeutic targets. In addition to VEGFR1/2, expression of PDGFR α/β in particular has been documented as characteristic of metastatic disease correlating with poor prognosis. Therefore, we have been suggested that the clinically approved multi-kinase ...

Journal: :American Journal of Physiology-Lung Cellular and Molecular Physiology 2018

2005
Rui M. Reis Albino Martins Susana A. Ribeiro Diana Basto Adhemar Longatto-Filho Fernando C. Schmitt José M. Lopes

Gliosarcomas are rare and poorly characterized malignant brain tumors that exhibit a biphasic tissue pattern with areas of gliomatous and sarcomatous differentiation. These tumors are histological variants of glioblastoma, displaying a similar genetic profile and dismal prognosis. Up-regulation of PDGFR subfamily of tyrosine kinase members, PDGFR-α and c-Kit, and their intracellular effectors R...

Journal: :Journal of surgical oncology 2011
Edward J Kim Mark M Zalupski

Progression on first-line therapy with imatinib in gastrointestinal stromal tumors (GIST) is caused by either initial resistance or more often a secondary mutation in tyrosine kinases KIT or PDGFR. Therapies in development for imatinib-resistant GIST include agents that target KIT/PDGFR with greater potency or possess broader kinase inhibition profiles including VEGFR. To circumvent secondary m...

Journal: :Neoplasia 2004
Matthias D Hofer Alice Fecko Ronglai Shen Sunita R Setlur Kenneth G Pienta Scott A Tomlins Arul M Chinnaiyan Mark A Rubin

The platelet-derived growth factor receptor (PDGFR) is a receptor tyrosine kinase overexpressed in a subset of solid tumors and therefore is the target of drugs inhibiting this function such as imatinib mesylate (Gleevec). Thus far, drug therapy has played a limited role in the treatment of localized prostate cancer (PCa). This study characterizes PDGFR-beta expression in a wide spectrum of PCa...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993
W J LaRochelle R A Jensen M A Heidaran M May-Siroff L M Wang S A Aaronson J H Pierce

A potent neutralizing monoclonal antibody to the human alpha platelet-derived growth factor (PDGF) receptor (alpha PDGFR) was raised by immunizing BALB/c mice with 32D cells expressing the human alpha PDGFR. This monoclonal antibody, designated alpha R1, immunoprecipitated human, monkey, rabbit, pig, dog, and cat, but not hamster, rat, or mouse alpha PDGFRs. Comparison with PR292, a monoclonal ...

2017
Yusuke Kurita Jun Araya Shunsuke Minagawa Hiromichi Hara Akihiro Ichikawa Nayuta Saito Tsukasa Kadota Kazuya Tsubouchi Nahoko Sato Masahiro Yoshida Kenji Kobayashi Saburo Ito Yu Fujita Hirofumi Utsumi Haruhiko Yanagisawa Mitsuo Hashimoto Hiroshi Wakui Yutaka Yoshii Takeo Ishikawa Takanori Numata Yumi Kaneko Hisatoshi Asano Makoto Yamashita Makoto Odaka Toshiaki Morikawa Katsutoshi Nakayama Kazuyoshi Kuwano

BACKGROUND Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation of profibrotic myofibroblasts is a crucial process for fibrotic remodeling in IPF. Recent findings show participation of autophagy/mitophagy, part of the lysosomal degradation machinery, in IPF pathogenesis. Mitophagy has bee...

Journal: :Cancer research 1992
M Hermanson K Funa M Hartman L Claesson-Welsh C H Heldin B Westermark M Nistér

The expression of platelet-derived growth factor (PDGF) and its receptors was analyzed in 14 gliomas of various degrees of malignancy and compared with three gliosis cases by in situ hybridization and immunohistochemistry techniques. Expression of both PDGF A- and B-chains was higher in glioblastomas than in astrocytomas. The PDGF A-chain mRNA was predominantly found in cell-rich areas in gliob...

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