The protein PCM-1 localizes to cytoplasmic granules known as "centriolar satellites" that are partly enriched around the centrosome. We inhibited PCM-1 function using a variety of approaches: microinjection of antibodies into cultured cells, overexpression of a PCM-1 deletion mutant, and specific depletion of PCM-1 by siRNA. All approaches led to reduced targeting of centrin, pericentrin, and n...

Centrosomes have many important functions and comprise a 'mother' and 'daughter' centriole surrounded by pericentriolar material (PCM). The mother centriole recruits and organises the PCM and templates the formation of the daughter centriole. It has been reported that several important Drosophila PCM-organising proteins are recruited to centrioles from the cytosol as part of large cytoplasmic '...

The electron transport through ultra-scaled amorphous phase change material (PCM) GeTe is investigated by using ab initio molecular dynamics, density functional theory, and non-equilibrium Green’s function, and the inelastic electron–phonon scattering is accounted for by using the Born approximation. It is shown that, in ultra-scaled PCM device with 6 nm channel length, <4 % of the energy carri...

Applying performance models to evaluate component-based enterprise applications in practice is becoming more and more difficult with an increasing organizational complexity. Components can be governed by different organizational units, are subject to a continuous shift between life cycle phases, and exhibit diverging release levels. Creating and maintaining performance models based on the compo...

The growing availability of big data has induced new storing and processing techniques implemented in big data systems such as Apache Hadoop or Apache Spark. With increased implementations of these systems in organizations, simultaneously, the requirements regarding performance qualities such as response time, throughput, and resource utilization increase to create added value. Guaranteeing the...

Chemistry Aware Model Builder Isidro Cortes-Ciriano∗1,5, Daniel S. Murrell†2,5, Gerard J. P. van Westen, Ian P. Stott, Andreas Bender, Therese E. Malliavin, and Robert C. Glen Unite de Bioinformatique Structurale, Institut Pasteur and CNRS UMR 3825, Structural Biology and Chemistry Department, 25-28, rue Dr. Roux, 75 724 Paris, France. Unilever Centre for Molecular Science Informatics, Departme...

Background: Acetaminophen (Paracetamol; PCM), commonly utilized as analgesic and antipyretic drug in many painful and febrile disorders, has been found to induce liver and renal disorders in both animals and humans. Its administration in a high dose causes hepatic and renal toxicities and results in hepato-renal cell deaths by activating multiple stress pathways. Objective: This study aimed to ...

In high-magnetic magnetic resonance imaging (MRI) systems (7 T and above), the radio frequency (RF) field shows greater inhomogeneity compared with clinical MRI systems (1.5 and 3.0 T). In multichannel RF coils, driving each coil element with convex optimisation can reduce non-uniformity of the RF field in a region of interest. In this Letter, a periodic compressed method (PCM) and a PCM after ...

This paper investigates the effects of Integral NonLinearity (INL) on the performances of both A/D converters and Digital Communication Systems, which exploit Direct Digital Modulation. The performances of both PCM and Sigma-Delta converters affected by INL are considered and compared. Then, the effects of INL upon the BER performances of an OFDM system are evaluated and modeled. The accuracy o...

BACKGROUND Naltrexone may improve success in primary care treatment of alcohol dependence (AD). This study tests naltrexone and primary care management (PCM) vs naltrexone and cognitive behavior therapy (CBT) and tests naltrexone maintenance among patients who respond to an initial course of naltrexone combined with PCM vs CBT. METHODS A nested sequence of 3 randomized trials was conducted. I...