Electrospinning is an effective method in preparing polymeric nanofibrous drug delivery systems (DDSs) for topical wound healing and skin burn therapy applications. The aim of the present study was to investigate a new synthetic graft copolymer (Soluplus) as a hydrophilic carrier polymer in electrospinning of nanofibrous DDSs. Soluplus (polyvinyl caprolactam-polyvinyl acetate-polyethylene glyco...

The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...

BACKGROUND The interaction of stem cells with their culture substrates is critical in controlling their fate and function. Declining stemness of adult-derived human mesenchymal stem cells (hMSCs) during in vitro expansion on tissue culture polystyrene (TCPS) severely limits their therapeutic efficacy prior to cell transplantation into damaged tissues. Thus, various formats of natural and synthe...

Abstract A crucial property for the evaluation of bioinks, besides biocompatibility, is printability, which determined by resolution and shape fidelity. Recently, fiber reinforcement was used to overcome rheological limitations introduce biomimetic structuring. This study provides a systematic approach evaluate printability reinforced hydrogels. Alginate Pluronic hydrogels were blended with cel...

The interest in biodegradable polymer nanofibres with tissue cell regeneration potential has increased recent years. However, there are issues the development of scaffolding to provide a favourable environment for proliferation and attachment. Such can be overcome by addition hydroxyapatite (HA), which is widely used biomaterial applications. Biodegradable polycaprolactone (PCL) (HA) have been ...

The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydroge...

Biopolymers are good carrier materials in relation to efficient release sustainability for encapsulated drugs. In particular, electrospun polymer/composite fibre membranes can offer greater benefits owing their competitive features as well large specific surface areas. this study, multiple nanofibre membrane systems were utilised including different material such poly(lactic acid) (PLA), poly(?...

Chronic wounds are a growing medical issue around the world, with 2.4 - 4.5 million people afflicted in United States alone. The condition currently makes up 2-3% of healthcare costs for developed countries, and this number is expected to increase as chronic wound-causing problems, like diabetes, grow prevalence. Due lack effective wound dressings, face higher risk bacterial infection express h...