Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination of PBB and to identify factors associated with eliminat...

Over an 11-yr period (1990-2000), a questionnaire survey on work environmental management and environmental improvement was conducted on 259 lead-handling factories and 7,623 subjects. Labour Inspection Offices identified these factories as requiring environmental improvement, or possessing a desire to improve their working environment. We analyzed factors affecting blood lead levels (PbBs). Th...

In health, microglia reside as quiescent guardian cells ubiquitously, but isolated without any cell-cell contacts amongst themselves, throughout the normal CNS. In disease, however, they act as swift "sensors" for pathological events, including subtle ones without any obvious structural damage. Once activated, microglia show a territorially highly restricted involvement in the disease process. ...

BACKGROUND Polybrominated biphenyl (PBB), a brominated flame retardant, was accidently mixed into animal feed in Michigan (1973-1974) resulting in human exposure through consumption of contaminated meat, milk and eggs. Beginning in 1976 individuals who consumed contaminated products were enrolled in the Michigan Long-Term PBB Study. This cohort presents a unique opportunity to study the associa...

Of the past recent, the use of e-business has been up-taken amazingly in various business sectors considering its characteristics of ubiquity, universal standards, global reach, richness, information density, interactivity, and personalization or customization of messages (Laudon & Traver, 2006). The growth is said to be stimulated by the increasing demand for data processing and storage, that ...

Between 1990 and 2008, a close collaboration between the Centre for Environment, Fisheries and Aquaculture Science (Cefas) and the UK Cetacean Strandings Investigation Programme (CSIP) has generated one of the largest time-series datasets on chemical contaminants in a marine mammal species the UK-stranded harbour porpoise (Phocoena phocoena). This dataset shows that some organochlorine pesticid...

Brominated flame retardants (BFRs), such as polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs) and tetrabromobisphenol-A (TBBP-A), have routinely been added to consumer products for several decades in a successful effort to reduce fire-related injury and property damage. Recently, concern for this emerging class o f chemicals has risen because o f their occurrence in the en...

Two studies (one in Holstein calves and one in Holstein cows) were conducted to determine potential toxicity and residue levels following oral ingestion of polybrominated biphenyls (PBB). The material was FireMaster FF-1. Administration was by gelatin capsules. Doses in calves were 0.1, 1.0, 10, or 100 mg/kg body weight, while doses in cows were equivalent to 0.01, 0.1, 1.0, or 10 ppm in the di...

Introduction Comprehensive two-dimensional gas chromatography (GC×GC) has gradually been introduced to solve some separation problems found during the analysis with one-dimensional GC. The use of high speed time-of-flight mass spectrometry (HS-ToF MS) as a detector for GC×GC (GC×GC–ToF MS) adds an additional dimension to the analysis allowing unambiguous determination based on nominal mass. Thi...